Antibacterial agents: salinamide derivatives
US-9605028-B2 · Mar 28, 2017 · US
US9809626B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9809626-B2 |
| Application number | US-201715436446-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 17, 2017 |
| Priority date | Dec 12, 2012 |
| Publication date | Nov 7, 2017 |
| Grant date | Nov 7, 2017 |
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The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.
Opening claim text (preview).
What is claimed is: 1. A method for preparing a compound: the method comprising the step of deprotecting a compound: by removing the tert-butyloxycarbonyl (Boc) group. 2. A method for preparing a compound: the method comprising the step of deprotecting a compound: by removing the tert-butyloxycarbonyl (Boc) group. 3. A compound selected from: or a salt thereof.
cyclic, e.g. valinomycins {; Derivatives thereof} · CPC title
Antibacterial agents · CPC title
Testing for antimicrobial activity of a material · CPC title
DNA-directed RNA polymerase (2.7.7.6) · CPC title
Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title
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