Compounds and methods for kinase modulation, and indications therefor
US-2017319559-A1 · Nov 9, 2017 · US
US9809562B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9809562-B2 |
| Application number | US-201515301485-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 2, 2015 |
| Priority date | Apr 3, 2014 |
| Publication date | Nov 7, 2017 |
| Grant date | Nov 7, 2017 |
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The invention relates to compounds in the treatment or prevention of disorders associated with Lamin A and/or Lamin C depletion or LMNA mutations, such as laminopathy, premature ageing disorders, normal ageing and cancer (such as a cancer characterized by low levels of LMNA expression).
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The invention claimed is: 1. A compound selected from: and salts or solvates of any one thereof. 2. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 3. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 4. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 5. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 6. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 7. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 8. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 9. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 10. A compound according to claim 1 , wherein the compound is or a salt or solvate thereof. 11. A pharmaceutical composition comprising a compound according to claim 1 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 12. A pharmaceutical composition comprising a compound according to claim 2 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 13. A pharmaceutical composition comprising a compound according to claim 3 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 14. A pharmaceutical composition comprising a compound according to claim 4 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 15. A pharmaceutical composition comprising a compound according to claim 5 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 16. A pharmaceutical composition comprising a compound according to claim 6 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 17. A pharmaceutical composition comprising a compound according to claim 7 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 18. A pharmaceutical composition comprising a compound according to claim 8 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 19. A pharmaceutical composition comprising a compound according to claim 9 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s). 20. A pharmaceutical composition comprising a compound according to claim 10 and one or more pharmaceutically acceptable carrier(s), diluents(s) and/or excipient(s).
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