Treatment of amyotrophic lateral sclerosis

Patent metadata

Field	Value
Publication number	US-9809556-B2
Application number	US-201514867624-A
Country	US
Kind code	B2
Filing date	Sep 28, 2015
Priority date	Nov 20, 2008
Publication date	Nov 7, 2017
Grant date	Nov 7, 2017

Abstract

The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.

First claim

We claim:

1. A compound selected from compounds of a formula

wherein each of R 1 -R 4 is independently selected from H, alkyl, cycloalkyl, alkylsulfonyl, alkylcarbonyl, aryl, arylalkyl, alkenylalkyl and alkynylalkyl moieties; each of R′ 1 -R′ 4 is independently selected from H, alkyl, amino, alkylamino, alkylsulfonyl, alkylcarbonyl, alkoxy, alkoxycarbonyl, cyano, and halo moieties; m is an integer selected from 0-3, and n is an integer selected from 1-3; and salts, tautomers and combinations thereof.

2. The compound of claim 1 wherein R 1 is alkyl.

3. The compound of claim 2 wherein each of R′ 1 and R′ 3 is chloro.

4. The compound of claim 2 wherein m is 0-1 and n is 1-2.

5. The compound of claim 2 wherein R 1 is selected from methyl and ethyl moieties.

6. The compound of claim 5 wherein m is 0-1 and n is 1-2.

7. The compound of claim 6 wherein each of R′ 1 and R′ 3 is chloro, and each of R 3 , R′ 2 and R′ 4 is H.

8. The compound of claim 7 in pharmaceutical composition comprising a carrier component.

9. A compound selected from compounds of a formula

wherein each of R 1 -R 4 is independently selected from H, alkyl, cycloalkyl, alkylsulfonyl, alkylcarbonyl, aryl, arylalkyl, alkenylalkyl and alkynylalkyl moieties; R′ is a halo moiety and m is an integer selected from 1-4; and n is an integer selected from 1-2, and salts, tautomers and combinations thereof.

10. The compound of claim 9 wherein R 1 is alkyl.

11. The compound of claim 10 wherein R′ is chloro and m is 2.

12. The compound of claim 11 wherein R 1 is selected from methyl and ethyl moieties, each of R 2 -R 4 is H and n is 1-2.

13. The compound of claim 12 in a pharmaceutical composition comprising a carrier component.

14. A compound selected from compounds of a formula

wherein each of R 1 -R 4 , R′ 2 , and R′ 4 is independently selected from H, alkyl, cycloalkyl, alkylsulfonyl, alkylcarbonyl, aryl, arylalkyl, alkenylalkyl and alkynylalkyl moieties; each of R′ 1 and R′ 3 is independently selected from H, alkyl, amino, alkylamino, alkylsulfonyl, alkylcarbonyl, alkoxy, alkoxycarbonyl, cyano, and halo moieties; and m is 0-1 and n is 1-2, and salts, tautomers and combinations thereof.

15. The compound of claim 14 wherein R 1 is alkyl.

16. The compound of claim 14 wherein each of R′ 1 and R′ 3 is chloro.

17. The compound of claim 14 wherein R 1 is selected from methyl and ethyl moieties.

18. The compound of claim 14 wherein each of R′ 1 and R′ 3 is chloro, and each of R 3 , R′ 2 and R′ 4 is H.

19. The compound of claim 14 in a pharmaceutical composition comprising a carrier component.

Assignees

• Univ Northwestern

Inventors

• Silverman Richard B
• Zhang Yinan

Classifications

• C07D403/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D401/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D498/04

  Ortho-condensed systems · CPC title

• C07D471/04

  Ortho-condensed systems · CPC title

• C07D231/18 Primary

  One oxygen or sulfur atom · CPC title