Bovine milk oligosaccharides

Patent metadata

Field	Value
Publication number	US-9808475-B2
Application number	US-201514871577-A
Country	US
Kind code	B2
Filing date	Sep 30, 2015
Priority date	Jul 12, 2010
Publication date	Nov 7, 2017
Grant date	Nov 7, 2017

Abstract

Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

First claim

What is claimed is:

1. A food product for a human or non-human animal, the food product comprising a powder composition comprising one or more oligosaccharide from bovine milk or bovine milk product and an inoculum of Bifidobacterium longum subsp. infantis or B. breve , wherein the oligosaccharide is from Table 1 and is selected from the group consisting of:
an oligosaccharide consisting of 3 Hexose (Hex) moieties, 4 N-acetyl hexosamine (HexNAc) moieties and 1 fucose (Fuc) moiety;
an oligosaccharide consisting of 4 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 3 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 5 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 4 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 3 Hex moieties, 6 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 3 Hex moieties and 6 HexNAc moieties,
an oligosaccharide consisting of 4 Hex moieties and 3 HexNAc moieties;
an oligosaccharide consisting of 3 Hex moieties and 4 HexNAc moieties;
an oligosaccharide consisting of 6 Hex moieties and 2 HexNAc moieties;
an oligosaccharide consisting of 4 Hex moieties and 4 HexNAc moieties;
an oligosaccharide consisting of 3 Hex moieties and 5 HexNAc moieties;
an oligosaccharide consisting of 5 Hex moieties and 4 HexNAc moieties;
an oligosaccharide consisting of 4 Hex moieties and 5 HexNAc moieties; and
a mixture thereof.

2. The food product of claim 1 , comprising at least two oligosaccharides selected from selected from the group consisting of:
an oligosaccharide consisting of 3 Hex moieties, 4 HexNAc moieties and 1 fucose (Fuc) moiety;
an oligosaccharide consisting of 4 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 3 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 5 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 4 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 3 Hex moieties, 6 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 3 Hexose (Hex) moieties and 6 N-acetyl hexosamine (HexNAc) moieties,
an oligosaccharide consisting of 4 Hex moieties and 3 HexNAc moieties;
an oligosaccharide consisting of 3 Hex moieties and 4 HexNAc moieties;
an oligosaccharide consisting of 6 Hex moieties and 2 HexNAc moieties;
an oligosaccharide consisting of 4 Hex moieties and 4 HexNAc moieties;
an oligosaccharide consisting of 3 Hex moieties and 5 HexNAc moieties;
an oligosaccharide consisting of 5 Hex moieties and 4 HexNAc moieties; and
an oligosaccharide consisting of 4 Hex moieties and 5 HexNAc moieties.

3. The food product of claim 1 , comprising one or more of
an oligosaccharide consisting of 3 Hex moieties, 4 HexNAc moieties and 1 fucose (Fuc) moiety;
an oligosaccharide consisting of 4 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 3 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 5 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;
an oligosaccharide consisting of 4 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety; or
an oligosaccharide consisting of 3 Hex moieties, 6 HexNAc moieties, and 1 Fuc moiety.

4. The food product of claim 1 , wherein the concentration of the oligosaccharide in the composition is from 100 micrograms/L to 25 grams/L.

5. The food product of claim 1 , wherein the composition is selected from the group consisting of a tablet, a capsule, a medical food, or a medical product.

6. The food product of claim 1 , wherein said food product is selected from the group consisting of an infant formula, follow-on formula, toddler's beverage, milk, fruit juice, and fruit-based drink.

7. The food product of claim 1 , wherein the oligosaccharide has been purified from bovine milk or a bovine milk product.

8. The food product of claim 1 , further comprising an inoculum of a fungus or yeast.

9. The food product of claim 1 , wherein the inoculum is an inoculum of Bifidobacterium longum subsp. infantis.

10. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties, 4 HexNAc moieties and 1 fucose (Fuc) moiety.

11. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety.

12. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety.

13. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 5 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety.

14. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety.

15. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties, 6 HexNAc moieties, and 1 Fuc moiety.

16. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties and 6 HexNAc moieties.

17. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties and 3 HexNAc moieties.

18. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties and 4 HexNAc moieties.

19. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 6 Hex moieties and 2 HexNAc moieties.

20. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties and 4 HexNAc moieties.

21. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties and 5 HexNAc moieties.

22. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 5 Hex moieties and 4 HexNAc moieties.

23. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties and 5 HexNAc moieties.

24. The food product of claim 1 , wherein the food product is an infant cereal or an adult cereal.

25. The food product of claim 1 , wherein the food product is a human food product.

26. The food product of claim 1 , wherein the food product is in dose form and the inoculum of Bifidobacterium longum subsp. infantis or B. breve is present at a level of from 10 4 to 10 12 cfu/dose.

Assignees

• Univ California

Inventors

• German J Bruce
• Mills David
• Lebrilla Carlito B
• Barile Daniela
• Locascio Riccardo

Classifications

• A61K31/726

  Glycosaminoglycans, i.e. mucopolysaccharides (chondroitin sulfate, dermatan sulfate A61K31/737) · CPC title

• A23L33/28

  Substances of animal origin, e.g. gelatin or collagen · CPC title

• A61K31/715

  Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• C12P19/18

  produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins · CPC title