Inhibitors of tyk2
US-2024425484-A1 · Dec 26, 2024 · US
US9808006B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9808006-B2 |
| Application number | US-201313948419-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 23, 2013 |
| Priority date | Jul 22, 2008 |
| Publication date | Nov 7, 2017 |
| Grant date | Nov 7, 2017 |
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A compound of formula (I) wherein A, p, R 1 , R 3 , R 4 , R 5 , R 6 , m, R 7 , n and R 8 are as defined in claim 1. Furthermore, the present invention relates to intermediates used to prepare compounds of formula (I), to methods of using them to combat and control insect, acarine, nematode and mollusc pests and to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising them.
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The invention claimed is: 1. A compound of formula (I): wherein A is CR 2 ; p is 0 or 1; R 1 is pyrid-4-yl optionally substituted by one or two substituents each independently selected from halogen, C 1 -C 3 alkyl or C 1 -C 3 haloalkyl; R 2 is hydrogen, halogen, C 1 -C 3 haloalkyl or C 1 -C 3 haloalkoxy; R 3 and R 4 are each independently hydrogen, halogen, cyano, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 2 -C 8 alkenyl, C 2 -C 8 haloalkenyl, C 3 -C 8 cycloalkyl, C 3 -C 8 halocycloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 haloalkoxy, C 1 -C 8 alkylthio or C 1 -C 8 haloalkylthio; R 5 is hydrogen or halogen; each R 6 and R 7 is independently halogen, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy or C 1 -C 8 haloalkoxy; m is 0, 1 or 2; n is 0, 1 or 2; and R 8 is halogen; or a salt thereof. 2. A compound according to claim 1 wherein R 1 is pyrid-4-yl optionally substituted by one or two substituents each independently selected from fluoro, chloro, bromo, methyl, difluoromethyl, chlorodifluoromethyl or trifluoromethyl. 3. A compound according to claim 1 wherein R 3 is hydrogen, halogen, cyano, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio or C 1 -C 6 haloalkylthio. 4. A compound according to claim 1 wherein R 4 is hydrogen, halogen, cyano, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 1 -C 6 alkylthio or C 1 -C 6 haloalkylthio. 5. A compound according to claim 1 wherein R 5 is hydrogen, fluoro, chloro or bromo. 6. A compound according to claim 1 wherein each R 6 is independently halogen, C 1 -C 6 alkyl or C 1 -C 6 alkoxy. 7. A compound according to claim 1 wherein m is 0 or 1. 8. A compound according to claim 1 wherein each R 7 is independently halogen, C 1 -C 6 alkyl or C 1 -C 6 alkoxy. 9. A compound according to claim 1 wherein n is 0 or 1. 10. An insecticidal, acaricidal, nematicidal or molluscicidal composition comprising an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I) as defined in claim 1 .
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