Sensor head for use with implantable devices

Patent metadata

Field	Value
Publication number	US-9804114-B2
Application number	US-201615059086-A
Country	US
Kind code	B2
Filing date	Mar 2, 2016
Priority date	Jul 27, 2001
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

First claim

What is claimed is:

1. A sensor for use in a glucose measuring device, the sensor comprising:
a plurality of electrodes, wherein the plurality of electrodes comprises a first electrode and a second electrode, wherein the first electrode comprises an electrochemically reactive surface;
a non-conductive body located between the first electrode and the second electrode; and
a multi-region membrane covering the plurality of electrodes, wherein the multi-region membrane comprises an immobilized enzyme domain comprising an enzyme in at least a portion thereof, wherein the immobilized enzyme domain covers and contacts the first electrode among the plurality of electrodes and does not cover and contact any other electrode of the plurality of electrodes.

2. The sensor of claim 1 , wherein the multi-region membrane further comprises a resistance domain.

3. The sensor of claim 1 , wherein the multi-region membrane comprises a silicone-containing copolymer.

4. The sensor of claim 3 , wherein the multi-region membrane further comprises an acrylate polymer.

Assignees

• Dexcom Inc

Inventors

• Rhodes Rathbun K
• Tapsak Mark A
• Brauker James H
• Shults Mark C

Classifications

• G01N27/3272 Primary

  Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels (optical biosensors G01N33/52) · CPC title

• G01N33/48707

  by electrical means (G01N33/49, G01N33/493 take precedence) · CPC title

• C12Q1/006

  for glucose · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• C12Q1/002

  Electrode membranes · CPC title