Virus causing respiratory tract illness in susceptible mammals

Patent metadata

Field	Value
Publication number	US-9803252-B2
Application number	US-201715453764-A
Country	US
Kind code	B2
Filing date	Mar 8, 2017
Priority date	Jan 19, 2001
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.

First claim

What is claimed is:

1. A kit for determining the presence of metapneumovirus (MPV) in a mammalian subject, the kit comprising:
a DNA probe of at least 10 nucleotides that specifically hybridizes to a target polynucleotide,
wherein the target polynucleotide comprises a sequence encoding a polypeptide that is at least 90% identical to SEQ ID NO: 14 or the complement of the sequence, and
wherein the DNA probe does not specifically hybridize to a polynucleotide from avian pneumovirus (APV).

2. The kit of claim 1 , wherein the DNA probe comprises at least 25 nucleotides.

3. The kit of claim 1 , wherein the DNA probe comprises at least 40 nucleotides.

4. The kit of claim 1 , wherein the DNA probe further comprises detectable marker.

5. The kit of claim 1 , wherein the target polynucleotide comprises a nucleic acid encoding SEQ ID NO: 14.

Assignees

• Univ Erasmus Med Ct Rotterdam

Inventors

• De Jong Jan Cornelius
• Fouchier Ronaldus Adrianus Maria
• Groen Jan
• Osterhaus Albertus Dominicus Marcellinus Erasmus
• Van Den Hoogen Bernadetta Gerarda

Classifications

• A61P37/04

  Immunostimulants · CPC title

• A61P31/14

  for RNA viruses · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• C07K16/11

  Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV] · CPC title

• C07K14/005

  from viruses · CPC title