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Baulamycins, compositions and methods of use thereof
US9803187B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9803187-B2 |
| Application number | US-201514717096-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 20, 2015 |
| Priority date | May 20, 2014 |
| Publication date | Oct 31, 2017 |
| Grant date | Oct 31, 2017 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
First claim
Opening claim text (preview).
What is claimed: 1. A method of inhibiting a nonribosomal peptide synthetase independent siderophore (NIS) synthetase comprising contacting the NIS synthetase with a composition comprising a pharmaceutically acceptable excipient and a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R 1 is a C 1-6 alkyl; said composition contacted in an amount sufficient to inhibit the NIS synthetase. 2. The method of claim 1 , wherein the NIS synthetase is a Type A NIS synthetase. 3. The method of claim 1 , wherein the NIS synthetase is AsbA or SbnE. 4. The method of claim 1 , wherein the compound of formula (I), or pharmaceutically acceptable salt thereof, has a stereochemistry as shown in formula (IA): 5. The method of claim 1 , wherein the compound of formula (I) has a structure or a pharmaceutically acceptable salt thereof. 6. The method of claim 1 , wherein the compound of formula (I) has a structure or a pharmaceutically acceptable salt thereof.
Assignees
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Classifications
having unsaturation outside the aromatic rings · CPC title
- C07C49/245Primary
containing six-membered aromatic rings · CPC title
by solid-liquid treatment; by chemisorption · CPC title
Ketones · CPC title
Ligases (6) · CPC title
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Frequently asked questions
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- What does patent US9803187B2 cover?
- Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
- Who is the assignee on this patent?
- Univ Michigan Regents, Asociación Inst Nac De Biodiversidad, Asoc Inst Nac De Biodiversidad
- What technology area does this patent fall under?
- Primary CPC classification C07C49/245. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 31 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).