Compositions and methods for viral sensitization
US-2024360115-A1 · Oct 31, 2024 · US
Process for the preparation of intermediates useful for the manufacture NEP inhibitors
US9802887B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9802887-B2 |
| Application number | US-201514739197-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 15, 2015 |
| Priority date | Aug 23, 2010 |
| Publication date | Oct 31, 2017 |
| Grant date | Oct 31, 2017 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
First claim
Opening claim text (preview).
The invention claimed is: 1. An isolated (Z)-isomer of a compound according to formula (5) having no (E)-isomer present, or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R is hydrogen or a C 1 -C 6 -alkyl residue. 2. The compound of formula (5) according to claim 1 wherein R1 is hydrogen; R2 is BOC or hydrogen; and R is hydrogen. 3. The compound of formula (5) according to claim 2 which is (Z)—(R)-5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid, or (Z)—(R)-4-Amino-5-biphenyl-4-yl-2-methyl-pent-2-enoic acid hydrochloride.
Assignees
Inventors
Classifications
with substituted hydrocarbon radicals, directly attached to ring carbon atoms · CPC title
- C07D207/38Primary
2-Pyrrolones · CPC title
by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates · CPC title
by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters · CPC title
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9802887B2 cover?
- The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
- Who is the assignee on this patent?
- Hook David, Riss Bernhard, Zhou Jianguang, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07D207/38. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 31 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).