Carrier for blood component adsorption and blood component adsorption column

Patent metadata

Field	Value
Publication number	US-9802178-B2
Application number	US-201113881172-A
Country	US
Kind code	B2
Filing date	Oct 26, 2011
Priority date	Oct 27, 2010
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

A carrier for blood component adsorption includes a water-insoluble carrier composed of a fiber or particle, the water-insoluble carrier having a surface to which a functional group(s) is/are introduced, the functional group(s) containing an acidic functional group selected from the group consisting of the sulfate group, sulfite group and sulfonate group; and containing an amino group; the fiber having a fiber diameter of, or the particle having a particle diameter of, 0.5 to 20 μm.

First claim

The invention claimed is:

1. A water-insoluble carrier comprising a fiber, said water-insoluble carrier having a surface to which functional groups are immobilized, said functional groups containing an acidic functional group selected from the group consisting of a sulfite group and sulfonate group; and containing a tertiary amino group,
said fiber having a fiber diameter of 0.5 to 20 um,
said water-insoluble carrier having a negative charge of 1.5×10 −5 to 1.5×10 −3 eq/g,
a material of said water-insoluble carrier composed of a fiber is at least one selected from the group consisting of polystyrenes, polypropylene, polypropylene-polyethylene copolymers, or poly(p-phenylene ether sulfone), and
said acidic functional group is positioned at a terminus of said functional group and said acidic functional group is positioned at a side not bound to said water-insoluble carrier.

2. The water-insoluble carrier according to claim 1 , wherein said water-insoluble carrier has a porosity of 85 to 98%, wherein said “porosity” is a ratio of a volume of voids in the water-insoluble carrier, and means a percentage value calculated by dividing the volume of voids in the water-insoluble carrier by an apparent volume of the water-insoluble carrier and said porosity is calculated by Equation (1):
Porosity (%)={( b−a )/ b }×100  (1)

a: The area of the part occupied by the water-insoluble carrier
b: The total area of the cross-section of the carrier for blood component adsorption.

3. The water-insoluble carrier according to claim 1 , wherein said water-insoluble carrier comprises fibers having a fiber diameter of 4 to 10 μm.

4. The water-insoluble carrier according to claim 1 , wherein said acidic functional group and said amino group are linked together via an alkyl chain.

5. The water-insoluble carrier according to claim 4 , wherein said alkyl chain is an alkyl chain having not more than 3 carbon atoms.

6. A column for blood component adsorption filled with a water-insoluble carrier comprising a fiber or particle, said water-insoluble carrier having a surface to which functional groups are immobilized, said functional groups containing an acidic functional group selected from the group consisting of a sulfite group and sulfonate group; and containing a tertiary amino group,
said fiber having a fiber diameter of 0.5 to 20 um, and
said water-insoluble carrier having a negative charge of 1.5×10 −5 to 1.5×10 −3 eq/g,
a material of said water-insoluble carrier composed of a fiber is at least one selected from the group consisting of polystyrenes, polypropylene, polypropylene-polyethylene copolymers, or poly(p-phenylene ether sulfone), and
said acidic functional group is positioned at a terminus of said functional group and said acidic functional group is positioned at a side not bound to said water-insoluble carrier.

7. The water-insoluble carrier according to claim 2 , wherein said water-insoluble carrier comprises fibers having a fiber diameter of 4 to 10 μm.

8. The water-insoluble carrier according to claim 2 , wherein said acidic functional group and said amino group are linked together via an alkyl chain.

9. The water-insoluble carrier according to claim 3 , wherein said acidic functional group and said amino group are linked together via an alkyl chain.

10. The column for blood component adsorption according to claim 6 , wherein said water-insoluble carrier has a porosity of 85 to 98%, wherein said “porosity” is a ratio of a volume of voids in the water-insoluble carrier, and means a percentage value calculated by dividing the volume of voids in the water-insoluble carrier by an apparent volume of the water-insoluble carrier and said porosity is calculated by Equation (1):
Porosity (%)={( b−a )/ b }×100  (1)

a: The area of the part occupied by the water-insoluble carrier
b: The total area of the cross-section of the carrier for blood component adsorption.

11. The column for blood component adsorption according to claim 6 , wherein said water-insoluble carrier has a porosity of 85 to 98%, and said water-insoluble carrier comprises fibers having a fiber diameter of 4 to 10 μm.

12. The column for blood component adsorption according to claim 6 , wherein said acidic functional group and said amino group are linked together via an alkyl chain.

13. The column for blood component adsorption according to claim 12 , wherein said alkyl chain is an alkyl chain having not more than 3 carbon atoms.

Assignees

• Tomita Naotoshi
• Ueno Yoshiyuki
• Tanahashi Kazuhiro
• Toray Industries

Inventors

• Tomita Naotoshi
• Ueno Yoshiyuki
• Tanahashi Kazuhiro

Classifications

• B01J20/28004

  Sorbent size or size distribution, e.g. particle size · CPC title

• B01J20/28016 Primary

  Particle form · CPC title

• A61M1/3679 Primary

  by absorption (A61M1/3675 takes precedence) · CPC title

• B01J20/28054

  characterised by their surface properties or porosity · CPC title

• B01J20/28023

  Fibres or filaments (fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence) · CPC title