Probiotic and polyphenol against neurodegeneration

Patent metadata

Field	Value
Publication number	US-9801915-B2
Application number	US-201314406980-A
Country	US
Kind code	B2
Filing date	Jun 20, 2013
Priority date	Jun 22, 2012
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

The present invention relates to a composition comprising the probiotic strain Lactobacillus johnsonii CNCM I-1225 in combination with a polyphenol for use in the treatment or prevention of a cognitive and/or neurodegenerative disorder, in particular Alzheimer's disease.

First claim

The invention claimed is:

1. A method of treatment comprising the step of administering a composition comprising Lactobacillus johnsonii CNCM 1-1225 in combination with a polyphenol to an individual in need of treatment of a cognitive and/or neurodegenerative disorder selected from the group consisting of Creutzfeldt-Jakob disease and Huntington's disease.

2. The method according to claim 1 , wherein the polyphenol is selected from the group consisting of rosmarinic acid, chicoric acid, caftaric acid, and combinations thereof.

3. The method according to claim 2 , wherein the rosmarinic acid is provided in the form of a rosemary extract.

4. The method according to claim 1 , wherein the polyphenol is provided in the form of a plant extract.

5. The method according to claim 1 , wherein the polyphenol is provided in the form of a pharmaceutically accepted salt.

6. The method according to claim 1 , wherein the Lactobacillus johnsonii CNCM I-1225 is in the form of viable bacteria or non-replicating bacteria.

7. The method according to claim 1 , wherein the composition comprises Lactobacillus johnsonii CNCM I-1225 in an amount of between 10 2 and 10 11 cfu/g dry mass of the composition.

8. The method according to claim 1 , wherein the Lactobacillus johnsonii CNCM I-1225 is encapsulated.

9. The method according to claim 1 , wherein the individual in need of same is a human or pet.

10. The method according to claim 1 , wherein the composition is selected from the group consisting of food products, animal food products, pharmaceutical compositions, nutritional formulations, nutraceuticals, beverages, food supplements, and food additives.

11. The method according to claim 1 , wherein the composition has a water activity of less than 0.2.

12. A method for treatment of a cognitive and/or neurodegenerative disorder selected from the group consisting of Creutzfeldt-Jakob disease and Huntington's disease, the method comprising administering a composition comprising Lactobacillus johnsonii CNCM I-1225 in combination with a polyphenol to an individual in need of same, wherein the polyphenol is in the form of a plant extract, and the Lactobacillus johnsonii CNCM I-1225 comprises 10 2 to 10 11 cfu/g dry mass of the composition.

Assignees

• Nestec Sa

Inventors

• Bel-Rhlid Rachid
• Durga Jane
• Kunz Tina
• Schmitt Jeroen Antonius Johannes

Classifications

• A61P25/16

  Anti-Parkinson drugs · CPC title

• A61P25/14

  for treating abnormal movements, e.g. chorea, dyskinesia · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61K31/216

  of acids having aromatic rings, e.g. benactizyne, clofibrate · CPC title