Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation

Patent metadata

Field	Value
Publication number	US-9801865-B2
Application number	US-58668109-A
Country	US
Kind code	B2
Filing date	Sep 24, 2009
Priority date	Sep 24, 2008
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

The subject invention concerns materials and methods for treating and/or preventing diseases associated with accumulation of Aβ peptide in neural tissue. The subject invention also concerns materials and methods for treating and/or preventing stress disorders, such as post-traumatic stress disorder (PTSD). In one embodiment, a method of the invention comprises administering a therapeutically effective amount of cotinine, or a pharmaceutically acceptable salt thereof, to a person or animal in need of treatment. The methods of the invention can be used to prevent and/or treat Alzheimer's disease and Parkinson's disease. The subject invention also concerns compositions that comprise cotinine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or adjuvant. The subject invention concerns materials and methods for detecting and diagnosing conditions associated with accumulation of Aβ peptide in neural tissue, such as Alzheimer's disease and Parkinson's disease, using the chemical cotinine.

First claim

I claim:

1. A method for treating a post-traumatic stress disorder or condition, said method comprising administering an amount of cotinine, or a composition comprising cotinine to a person or animal in an effective amount in order to enhance the extinction of fear memory in a person or animal in need of treatment and thereby treating the subject with the PTSD or condition.

Assignees

• Moran Valentina Echeverria
• The Us Dept Of Veteran Affairs
• Univ South Florida

Inventors

• Moran Valentina Echeverria

Classifications

• A61K51/0455

  having six-membered rings with one nitrogen as the only ring hetero atom · CPC title

• A61K31/4439 Primary

  containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465) · CPC title

• C07D401/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• A61P25/26

  Psychostimulants, e.g. nicotine, cocaine · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title