Oral care compositions and methods

Patent metadata

Field	Value
Publication number	US-9801795-B2
Application number	US-201315106652-A
Country	US
Kind code	B2
Filing date	Dec 20, 2013
Priority date	Dec 20, 2013
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

Provided is an oral care composition comprising a phosphate/acrylate co-polymer, a whitening agent and an orally acceptable carrier and methods of using the same.

First claim

What is claimed is:

1. An oral care composition comprising a phosphate/acrylate co-polymer, a whitening agent, and an orally acceptable carrier, wherein the phosphate/acrylate co-polymer is a co-polymerized product of a mixture of acrylic acid, methacrylic acid, and a mixture of 2-hydroxyethyl methacrylate phosphates of Formula 1:

wherein n is 0, 1 or 2.

2. The composition of claim 1 , wherein the composition comprises 0.1 weight % to 10 weight % of the phosphate/acrylate co-polymer.

3. The composition of claim 1 , wherein the phosphate/acrylate co-polymer is a co-polymerized product of a mixture of acrylic acid, methacrylic acid, and 2-hydroxyethyl methacrylate phosphates of Formula 1 comprising acrylic acid in a molar percentage of 70-90%; methacrylic acid in a molar percentage of 5-20%, and hydroxyethyl methacrylate phosphates of Formula 1 in a molar percentage of 1-10%.

4. The composition of claim 1 , wherein the phosphate/acrylate co-polymer is a co-polymerized product of a mixture of acrylic acid, methacrylic acid, and 2-hydroxyethyl methacrylate phosphates of Formula 1 comprising acrylic acid in a molar percentage of 80-90% or 85%; methacrylic acid in a molar percentage of 5-15% or 11%, and hydroxyethyl methacrylate phosphates of Formula 1 in a molar percentage of 2-6% or 4%.

5. The composition of claim 1 , wherein the phosphate/acrylate copolymer is a random copolymer having a weight average molecular weight of 10,000 to 500,000, and the phosphate/acrylate copolymer is below its glass transition temperature.

6. The composition of claim 5 , wherein the weight average molecular weight is 10,000 to 200,000 grams per mole, optionally, 10,000 to 40,000, 15,000 to 25,000, or 17,000 to 23,000 grams per mole.

7. The composition of claim 1 , wherein the whitening agent is a peroxide.

8. The composition of claim 1 , wherein the whitening agent is hydrogen peroxide.

9. The composition of claim 1 , comprising one or more polyphosphate salts.

10. The composition of claim 1 , comprising one or more polyphosphate salts selected from the group consisting of metal hexametaphosphate salts, sodium hexametaphosphate, tripolyphosphate salts, sodium tripolyphosphate, pyrophosphate salts, and sodium acid pyrophosphate.

11. The composition of claim 1 , comprising one or more surfactant, one or more detergent, one or more emulsifier, or any combination thereof.

12. The composition of claim 11 , wherein the surfactants, detergents and emulsifiers are selected from the group consisting of poloxamers and polysorbates.

13. The composition of claim 11 , wherein the surfactants or detergents are poloxamer 407 and polysorbate 20.

14. The composition of claim 1 , further comprising one or more antibacterial or antiseptic agents.

15. The composition of claim 14 , wherein the antibacterial or antiseptic agents are selected from the group consisting of menthol, methyl salicylate, and combinations thereof.

16. The composition of claim 14 , wherein the anti-bacterial agent is selected from the group consisting of triclosan, cetylpyridinium chloride (CPC), chlorhexidine (CHX), water soluble zinc salts, water insoluble zinc salts, zinc oxide, zinc citrate, stannous salts, and mixtures thereof.

17. The composition of claim 1 , wherein the orally acceptable carrier comprises water and humectant selected from one or more of a sugar alcohol, an alkylene glycol, glycerin, or combination thereof.

18. The composition of claim 17 , wherein the orally acceptable carrier comprises water, sorbitol and propylene glycol.

19. The composition of claim 1 , wherein the composition is a mouth rinse.

20. The composition of claim 1 , comprising:
phosphate/acrylate co-polymer in an amount of from 0.1% to 5%;
hydrogen peroxide in an amount of from 0.01% to 4%; and
one or more polyphosphate salts in an aggregate amount of from 0.1% to 3%.

21. The composition of claim 20 , wherein, the polyphosphate salts comprise sodium hexametaphosphate.

22. A method for the treatment and/or inhibition of a chemical stain, plaque, acid erosion, and/or tartar on a dental surface, comprising contacting the dental surface with a composition of claim 1 .

23. A method for the treatment and/or inhibition of gum disease comprising contacting the oral cavity with a composition of claim 1 .

24. A method for the treatment and/or inhibition of halitosis comprising contacting the oral cavity with a composition of claim 1 .

25. A method for the inhibition of biofilm formation on a dental surface comprising contacting the oral cavity with a composition of claim 1 .

Assignees

• Colgate Palmolive Co

Inventors

• Nesta Jason
• Szewczyk Gregory
• Arvanitidou Evangelia
• Mijalis Alexander

Classifications

• A61K8/347

  Phenols · CPC title

• A61K8/345

  containing more than one hydroxy group · CPC title

• A61K8/8147

  Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K8/8164

  Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride) · CPC title