Advanced analyte sensor calibration and error detection

Patent metadata

Field	Value
Publication number	US-9801575-B2
Application number	US-201213446848-A
Country	US
Kind code	B2
Filing date	Apr 13, 2012
Priority date	Apr 15, 2011
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

First claim

What is claimed is:

1. A system for measuring an analyte, the system comprising sensor electronics configured to be operably connected to a continuous analyte sensor, the sensor electronics configured to:
apply a time-varying signal to the analyte sensor;
measure a peak current from the sensor in response to the applied signal;
determine a sensitivity of the analyte sensor, the determining comprising correlating the peak current to a predetermined sensor sensitivity curve that is a representation of a change in sensitivity over time, the determining further comprising selecting the predetermined sensitivity curve based on the peak current from a plurality of different predetermined sensitivity curves; and
generate estimated analyte concentration values using the determined sensitivity and sensor data generated by the analyte sensor.

2. The system of claim 1 , wherein the sensitivity curve comprises varying sensitivity values over time since implantation of the sensor.

3. The system of claim 1 , wherein the predetermined sensitivity curve comprises a plurality of sensitivity values.

4. The system of claim 1 , wherein the predetermined sensitivity curve is based on sensor sensitivity data generated from studying sensitivity changes of analyte sensors similar to the analyte sensor.

5. The system of claim 1 , wherein the sensor electronics are further configured to apply a bias voltage to the sensor, wherein the time-varying signal comprises a step voltage above the bias voltage or a sine wave overlaying a voltage bias voltage.

6. The system of claim 1 , wherein the determining further comprises calculating an impedance value based on the peak current and correlating the impedance value to a sensitivity value of the predetermined sensitivity curve.

7. The system of claim 1 , wherein the sensor electronics are further configured to apply a DC bias voltage to the sensor to generate sensor data, wherein the generating the estimated analyte concentration values includes correcting the generated sensor data based on the measured response.

8. The system of claim 7 , wherein the sensor electronics are further configured to apply a conversion function to the corrected sensor data to generate the estimated analyte concentration values.

9. The system of claim 1 , wherein the sensor electronics are further configured to form a conversion function based at least in part of the determined sensitivity, and wherein the conversion function is applied to the sensor data to generate the estimated analyte concentration values.

10. The system of claim 1 , wherein the selecting includes performing a data association analysis to determine a correlation between the peak current and each of the plurality of different predetermined sensitivity curves and wherein the selected predetermined sensitivity curve has the highest correlation.

11. The system of claim 1 , wherein the sensor electronics are further configured to determine the sensitivity using the selected sensitivity curve.

12. The system of claim 11 , wherein the sensor electronics are further configured to determine a second sensitivity using the selected sensitivity curve, wherein a first set of estimated analyte concentration values is generated using the determined sensitivity and sensor data associated with a first time period, and wherein a second set of concentration values is generated using the second sensitivity and sensor data associated with a second time period.

13. The system of claim 1 , wherein the sensor electronics comprise a processor module, the processor module comprising instructions stored in computer memory, wherein the instructions, when executed by the processor module, cause the sensor electronics to perform the applying, the measuring, the determining and the generating.

14. The system of claim 1 , wherein determining the sensitivity further includes modifying the predetermined sensitivity curve based on the peak current, wherein the modified sensitivity curve more closely models the analyte sensor's actual sensitivity curve.

15. A method for measuring an analyte using a continuous analyte sensor, the method comprising:
applying a time-varying signal to the analyte sensor;
measuring a peak current;
using sensor electronics, determining a sensitivity of the analyte sensor, the determining comprising correlating the peak current to a predetermined sensor sensitivity curve that is a representation of a change in sensitivity over time, the determining further comprising selecting the predetermined sensitivity curve based on the peak current from a plurality of different predetermined sensitivity curves; and
using said sensor electronics, generating estimated analyte concentration values using the determined sensitivity and sensor data generated by the analyte sensor.

16. The method of claim 15 , wherein the sensitivity curve comprises varying sensitivity values over time since implantation of the sensor.

17. The method of claim 15 , wherein the predetermined sensitivity curve comprises a plurality of sensitivity values.

18. The method of claim 15 , wherein the predetermined sensitivity curve is based on sensor sensitivity data generated from studying sensitivity changes of analyte sensors similar to the analyte sensor.

19. The method of claim 15 , further comprising applying a bias voltage to the sensor, wherein the time-varying signal comprises a step voltage above the bias voltage or a sine wave overlaying a voltage bias voltage.

20. The method of claim 15 , wherein the determining further comprises calculating an impedance value based on the peak current and correlating the impedance value to a sensitivity value of the predetermined sensitivity curve.

21. The method of claim 15 , further comprising applying a DC bias voltage to the sensor to generate sensor data, wherein the generating estimated analyte concentration values includes correcting the generated sensor data based on the measured response.

22. The method of claim 21 , further comprising applying a conversion function to the corrected sensor data to generate the estimated analyte concentration values.

23. The method of claim 21 , further comprising forming a conversion function based at least in part of the determined sensitivity, and wherein the conversion function is applied to the sensor data to generate the estimated analyte concentration values.

24. The method of claim 21 , wherein the selecting includes performing a data association analysis to determine a correlation between the peak current and each of the plurality of different predetermined sensitivity curves and wherein the selected predetermined sensitivity curve has the highest correlation.

25. The method of claim 21 , further comprising determining the sensitivity using the selected sensitivity curve.

26. The method of claim 25 , further comprising determining a second sensitivity using the selected sensitivity curve, wherein a first set of estimated analyte concentration values is generated using the determined sensitivity and sensor data associated with a first time period, and wherein a second set of concentration values is generated using the second sensitivity and sensor data associated with a second time period.

27. The method of claim 21 , wherein determining the sensitivity further includes modifying the predetermined sensitivity curve based on the peak current, wherein the modified sensitivity

Assignees

• Bohm Sebastian
• Rong Daiting
• Simpson Peter C
• Dexcom Inc

Inventors

• Bohm Sebastian
• Rong Daiting
• Simpson Peter C

Classifications

• G01N33/49

  Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} · CPC title

• A61B5/1473

  invasive, e.g. introduced into the body by a catheter · CPC title

• G01N27/3274

  Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration (coding of calibration information G01N33/48771) · CPC title

• A61B5/1486

  using enzyme electrodes, e.g. with immobilised oxidase · CPC title

• A61B2560/0276

  Determining malfunction · CPC title