Self-assembling polymer particle release system

Patent metadata

Field	Value
Publication number	US-9801371-B2
Application number	US-201113884542-A
Country	US
Kind code	B2
Filing date	Nov 10, 2011
Priority date	Nov 10, 2010
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

Self-assembly is defined as the ability of an active ingredient (AI), when mixed with a polymer or polymers (solid or liquid state), to form either a complex or a strong attraction with the polymer/polymers, which influences the controlled release of the total system. This AI-polymer interaction or strong attraction can form in the solid state or in solution. The AI-polymer interaction also can form when applied to a filter paper, soil, seeds, or plant vegetation substrates, where the AI and polymer self-assembles into an AI-polymer-substrate matrix or complex that influences how the AI releases from the complex or matrix in a controlled manner.

First claim

We claim:

1. A method for constructing a self-assembling polymeric particle bearing an active ingredient (“AI”) and for treating soil or plant surfaces, which comprises the steps of:
(a) determining a solubility parameter for an AI;
(b) comparing the solubility parameter of the AI with a solubility parameter of a set of first polymers and selecting a first polymer having a Hansen solubility parameter, which is the total Hansen solubility parameter (δT) or any of δd, δh, δp, that is within at least 2 MPa 0.5 of a Hansen solubility parameter of the AI for forming an AI/first polymer stable blend, and forming the AI/first polymer stable blend;
(c) determining a second polymeric interface control agent having a Hansen solubility parameter that is at least 2 MPa 0.5 different than a Hansen solubility parameter of the first polymer in the AI/first polymer stable blend, and blending said second polymeric interface control agent with said AI/first polymer blend to form a second blend;
(d) making a water stable blend of said second blend; and
(e) depositing said water stable blend upon a surface to form a self-assembled polymeric particle,
said self-assembled polymeric particle having a core of said AI with said first polymer and said second polymeric interface control agent.

2. The method of claim 1 , wherein the AI is combined with solubility parameter matched free radical or condensation type monomers, which monomers are polymerized in the presence of the AI to form nanometer or micrometer size AI encapsulated polymers.

3. The method of claim 1 , wherein the AI is combined with polymer stabilizers and emulsified in water to form a nanometer or micrometer size emulsion that contains said AI.

4. The method of claim 1 , wherein the solubility parameter matched first polymer is formed into nanometer or micrometer size particles and the AI is incorporated into said first polymer particles by contacting with an aqueous or non-aqueous dispersion of said AI or by vapor diffusing said AI into said first polymer particles.

5. The method of claim 1 , wherein the solubility parameter matched first polymer is formed into a water/oil or oil/water emulsion of nanometer or micrometer sized particles of said solubility parameter matched first polymer and wherein the AI is diffused into the emulsion and becomes stabilized.

6. The method of claim 1 , wherein said second blend is not stable in water and further comprising adding an additive to make the second blend stable in water.

7. The method of claim 1 , wherein said self-assembling polymer particles are applied to one or more of soil, seed, or plant leaf.

8. The method of claim 1 , wherein said AI is one or more of a fungicide, insecticide, or herbicide.

9. The method of claim 1 , wherein said AI functions as a soil treatment, leaf treatment, seed treatment, or insect treatment.

10. The method of claim 1 , wherein said AI is a natural product.

11. The method of claim 1 , wherein said AI is one or more of a solid, liquid, solids dispersion in water, solids dispersion in an organic solvent, solids dispersion in a vegetable oil, homogeneous solution in water, homogeneous solution in an organic solvent, or homogeneous solution in a vegetable oil.

Assignees

• Mcginniss Vincent D
• Whitmore Jr Robert S
• Monson K David
• Roshon Melissa S
• Spahr Kevin B
• Risser Steven M
• Battelle Memorial Institute

Inventors

• Mcginniss Vincent D
• Whitmore Jr Robert S
• Monson K David
• Roshon Melissa S
• Spahr Kevin B
• Risser Steven M

Classifications

• A01N25/10

  Macromolecular compounds · CPC title

• A01N25/34

  Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group · CPC title

• A01N25/28 Primary

  Microcapsules {or nanocapsules} · CPC title

• B01J13/18

  In situ polymerisation with all reactants being present in the same phase · CPC title

• B01J13/22

  Coating · CPC title