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US-12180196-B2 · Dec 31, 2024 · US
Process for the preparation of gadobenate dimeglumine complex in a solid form
US9795695B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9795695-B2 |
| Application number | US-201615130160-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 15, 2016 |
| Priority date | Nov 23, 2009 |
| Publication date | Oct 24, 2017 |
| Grant date | Oct 24, 2017 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.
First claim
Opening claim text (preview).
The invention claimed is: 1. A process for the preparation of a solid, pharmaceutical form of gadobenate dimeglumine compound of formula (I): comprising spray-drying an aqueous composition of said compound, wherein the form is a stable water soluble powder having a particle size from 1 μm to 200 μm, wherein said aqueous composition has a concentration from 0.2 M to 0.8 M gadobenate dimeglumine, and wherein the inlet temperature (T-inlet) of the spray-drier is comprised from 140° C. to 200° C. and the outlet temperature (T-outlet) is comprised from 70° C. to 120° C. 2. The process according to claim 1 , wherein said concentration is comprised from 0.45 M to 0.55 M. 3. The process according to claim 1 , wherein said aqueous composition is a purified water solution. 4. The process according to claim 1 , comprising an atomization of the aqueous composition by using a pressure or a two-fluid nozzle. 5. The process according to claim 3 , comprising an atomization of the aqueous composition by using a pressure or a two-fluid nozzle.
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Classifications
Separation; Purification; Stabilisation; Use of additives · CPC title
characterised by the choice of material · CPC title
Separation; Purification · CPC title
- A61K9/0019Primary
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title
- C07C227/38Primary
Separation; Purification; Stabilisation; Use of additives (separation of optical isomers C07C227/34) · CPC title
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- What does patent US9795695B2 cover?
- The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a so…
- Who is the assignee on this patent?
- Bracco Imaging Spa
- What technology area does this patent fall under?
- Primary CPC classification A61K9/0019. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 24 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).