Pharmaceutical diagnostic

Patent metadata

Field	Value
Publication number	US-9795596-B2
Application number	US-201314387653-A
Country	US
Kind code	B2
Filing date	Mar 27, 2013
Priority date	Mar 29, 2012
Publication date	Oct 24, 2017
Grant date	Oct 24, 2017

Abstract

The present invention relates to selective cancer treatment regimes based on assaying for the presence or absence of a glutamine or a nucleic acid that encodes glutamine at position 859 of the catalytic p110α subunit of PI3K; methods for producing a transmittable form of information for predicting the responsiveness of patient to (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide), or a pharmaceutically acceptable salt thereof; and a kit thereof.

First claim

What is claimed is:

1. A method of selectively treating a subject having breast cancer, a tumor of the head and neck, kidney cancer, or pancreatic cancer, comprising:
a) assaying a biological sample from the subject for the presence or absence of a glutamine at position 859 of the catalytic p110α subunit of PI3K, and selectively administering a therapeutically effective amount of (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof, to the subject on the basis that the sample has a glutamine at position 859;
or
b) assaying a biological sample from the subject for the presence or absence of a nucleic acid sequence that encodes a glutamine at position 859 of the catalytic p110α subunit of PI3K, and selectively administering a therapeutically effective amount of (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof, to the subject on the basis that the sample has a nucleic acid sequence that encodes a glutamine at position 859.

2. A method of selectively treating a subject having breast cancer, a tumor of the head and neck, kidney cancer, or pancreatic cancer, comprising:
a) assaying a biological sample from the subject for the presence or absence of nucleic acid sequence mutation in the catalytic p110α subunit of PI3K, wherein the mutation results in an amino acid substitution of glutamine at position 859 of the catalytic p110α subunit of PI3K;
b) thereafter selecting the subject for treatment with (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide), or a pharmaceutically acceptable salt thereof, on the basis that the sample from the subject lacks the mutation and encodes glutamine at position 859 of the catalytic p110α subunit of PI3K; and
c) thereafter administering (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof to the subject lacking the mutation.

Assignees

• Furet Pascal
• Fritsch Christine
• Maira Sauveur-Michel
• Novartis Ag

Inventors

• Furet Pascal
• Fritsch Christine
• Maira Sauveur-Michel

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• C12Q1/6886

  for cancer (immunoassay for cancer G01N33/575) · CPC title

• A61K31/4439 Primary

  containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465) · CPC title

• C12Q2600/106

  Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism · CPC title