Gamma-diketones for treatment and prevention of aging skin and wrinkles

Patent metadata

Field	Value
Publication number	US-9795550-B2
Application number	US-201514831456-A
Country	US
Kind code	B2
Filing date	Aug 20, 2015
Priority date	Aug 20, 2014
Publication date	Oct 24, 2017
Grant date	Oct 24, 2017

Abstract

The present disclosure relates to compounds, cosmetic or dermopharmaceutical compositions comprising the same, and methods for using the compounds or compositions for treating, protecting, and/or improving the condition and/or aesthetic appearance of skin, for example, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, or improving the appearance of fine lines and/or or wrinkles of skin comprising application of the compounds or compositions disclosed. In some embodiments, the compounds useful in the methods described herein include compounds of Formula I:

or a dermatologically acceptable salt thereof.

First claim

What is claimed is:

1. A method for improving the aesthetic appearance of a subject's skin, the method comprising administering to the subject an effective amount of a compound of Formula I, or a dermatologically acceptable salt thereof:

wherein:
Ring A is a 7-12 membered heteroaryl, with the proviso that a carbon atom on the ring is attached to the carbonyl carbon;
Ring B is phenyl;
R 1 is a substituent attached to Ring A and is independently selected at each occurrence from the group consisting of unsubstituted —C 1-6 alkyl, —C 1-3 haloalkyl, halide, —OR 3 , and CN;
R 2 is a substituent attached to Ring B and is independently selected at each occurrence from the group consisting of unsubstituted —C 1-6 alkyl, —CH 2 OH, —CH 2 N(R 3b ) 2 , —C 1-3 haloalkyl, halide, —OR 3 , and CN;
each R 3 is independently selected from the group consisting of H, unsubstituted —C 1-6 alkyl, and —C 1-3 haloalkyl;
each R 3b is independently selected from the group consisting of H and unsubstituted —C 1-3 alkyl;
each n is 0 to 10; and
each m is 0 to 5.

2. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

3. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

4. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

5. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

6. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

7. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

8. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

9. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

10. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

11. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

12. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

13. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

14. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

15. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

or a dermatologically acceptable salt thereof.

16. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

Assignees

• Samumed Llc

Inventors

• Hood John
• Kc Sunil Kumar
• Kibar Osman
• Barroga Charlene F

Classifications

• A61K8/69

  containing fluorine · CPC title

• A61K8/49

  containing heterocyclic compounds · CPC title

• A61K8/494

  with more than one nitrogen as the only hetero atom · CPC title

• A61Q19/007

  Preparations for dry skin · CPC title

• A61K8/4926

  having six membered rings · CPC title