System and method for mass spectrometry imaging
US-2024389905-A1 · Nov 28, 2024 · US
US9795443B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9795443-B2 |
| Application number | US-91415406-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 8, 2006 |
| Priority date | May 12, 2005 |
| Publication date | Oct 24, 2017 |
| Grant date | Oct 24, 2017 |
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The invention relates to a device ( 1 ) for hair-growth control of hairs ( 3 ), in particular hairs growing from human skin ( 5 ). The device ( 1 ) has a laser source ( 7 ) for generating a laser beam ( 9 ) during a pulse time, an optical system ( 15 ) for focusing the laser beam into a focal spot ( 25 ), and a laser beam manipulator ( 17 ) for positioning the focal spot in a target position. According to the invention, a dimension of the focal spot ( 25 ) and a power of the generated laser beam ( 9 ) are such that, in the focal spot ( 25 ), the laser beam has a power density which is above a characteristic threshold value for hair-growth related skin tissue above which, for the pulse time, a laser induced optical breakdown (LIOB) phenomenon occurs in the hair-growth related skin tissue. The LIOB phenomenon results in a number of mechanical effects, such as cavitation and the generation of shock waves, which damage the hair-growth related skin tissue in positions surrounding the LIOB phenomenon. An advantage of the device ( 1 ) according to the invention is that the amount of total energy which is necessary to cause trauma and induce (semi-)permanent cessation of hair-growth is at such a level that irritation and damage of the surrounding skin tissue is very limited or even completely prevented.
Opening claim text (preview).
The invention claimed is: 1. A hair-growth control device, comprising: a laser beam source for providing a laser beam with a pulse time, a laser beam guiding means, a control unit for automatically determining a target position and focus depth for the laser beam, wherein the control unit is arranged to determine as the target position a position within a predetermined distance from hair-growth related skin tissue, which is situated between 0.3 and 5 mm below the surface of a skin to be treated when the device is in an operative position on the skin, and an optical focusing system for focusing the laser beam to a focal spot with a power density, wherein the power density in the focal spot is above a local threshold value of the corresponding tissue for inducing a laser induced optical breakdown phenomenon in skin tissue. 2. The device of claim 1 , wherein the laser beam guiding means comprises an adjustable laser beam manipulator. 3. The device of claim 1 , wherein the laser beam guiding means comprises an optical waveguide that is suitable for insertion into a hair follicle, and arranged for guiding the laser beam to an exit opening of the waveguide. 4. The device of claim 1 , further comprising an image sensor for detecting an image of at least a portion of the skin, wherein the control unit is arranged to determine the target position from the detected image. 5. The device of claim 1 , wherein the predetermined distance is less than or equal to 50 μm. 6. The device of claim 1 , wherein the hair-growth related skin tissue comprises hair follicle tissue and/or blood vessels feeding said follicle tissue. 7. The device of claim 6 , wherein the follicle tissue comprises at least one of a matrix, a dermal papilla, a hair bulb, an outer root sheath and stem cells of the hair follicle. 8. The device of claim 4 , wherein the image sensor comprises an ultrasound imaging system or an infrared imaging system. 9. A method of hair-growth control, comprising: generating a laser beam during a pulse time, determining a target position and focus depth for the laser beam, focusing said laser beam to a focal spot in skin tissue corresponding to the target position and focus depth, within a predetermined distance from a target in hair-growth related skin tissue relating to a hair of the skin, wherein the power density in the focal spot is, for the pulse time, above a local threshold value of the corresponding tissue for inducing a laser induced optical breakdown phenomenon in skin tissue at the focal spot, wherein the target position and focus depth are automatically determined by a control unit. 10. The method of claim 9 , wherein said predetermined distance is substantially zero. 11. The method of claim 9 , wherein the hair-growth related skin tissue comprises hair follicle tissue and/or blood vessels feeding said follicle tissue. 12. The method of claim 11 , wherein the follicle tissue comprises at least one of a matrix, a dermal papilla, a hair bulb, an outer root sheath and stem cells of the hair follicle. 13. The method of claim 9 , wherein a total pulse energy delivered to the focal spot is less than 1 mJ. 14. The method of claim 9 , wherein all the energy delivered to the hair-growth related skin tissue of each hair is delivered with a single pulse. 15. The method of claim 9 , wherein a total pulse energy delivered to the focal spot is less than 0.5 mJ. 16. The method of claim 9 , wherein a total pulse energy delivered to the focal spot is 0.2 mJ.
applying laser energy to the outside of the body · CPC title
Automatic detection of target tissue · CPC title
Hair follicles · CPC title
Skin · CPC title
using laser · CPC title
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