Material differentiation with phase contrast imaging

Patent metadata

Field	Value
Publication number	US-9795350-B2
Application number	US-201615294807-A
Country	US
Kind code	B2
Filing date	Oct 17, 2016
Priority date	Dec 21, 2012
Publication date	Oct 24, 2017
Grant date	Oct 24, 2017

Abstract

A method and system to determine material composition of an object comprises capturing a series of digital radiographic images of the object using a single exposure energy level. An intensity of the captured images is determined as well as phase shift differences. A difference in material composition of the object may be determined based on a combination of the determined intensity and the modulated phase shifts of the captured images.

First claim

What is claimed is:

1. A method of determining material composition of a portion of an animal body, the method comprising:
capturing a series of digital radiographic images of the portion of the animal body using an x-ray beam;
determining a phase shift magnitude that occurred in the portion of the animal body using the captured radiographic images of the portion of the animal body;
generating a differential phase shift image of the portion of the animal body;
generating an integrated phase image of the portion of the animal body; and
generating and displaying a radiographic image of the portion of the animal body including separately displaying within the radiographic image of the portion of the animal body a first type soft tissue and a second type soft tissue inside the portion of the animal body based on a combination of the differential phase shift image and the integrated phase image.

2. The method of claim 1 , wherein the step of generating and displaying a radiographic image of the portion of the animal body includes separately displaying within the radiographic image of the portion of the animal body two different non-bony soft tissues inside the portion of the animal body.

3. The method of claim 2 , wherein the step of generating and displaying a radiographic image of the portion of the animal body includes separately displaying within the radiographic image of the portion of the animal body glandular and adipose tissue inside the portion of the animal body.

4. The method of claim 1 , wherein the step of capturing comprises using a digital detector, the digital detector comprising a plurality of pixels, and wherein the step of determining the phase shift magnitude is performed for each pixel.

5. The method of claim 4 , further comprising determining an intensity of the captured radiographic images of the portion of the animal body, and wherein the step of determining the intensity is performed for each pixel.

6. The method of claim 4 , wherein the step of capturing comprises positioning a plurality of gratings in a path of the x-ray beam and phase stepping only a first one of the gratings into a different position for capturing each of the radiographic images.

7. The method of claim 6 , wherein the step of phase stepping comprises repositioning the first one of the gratings an equal distance for each of a plurality of phase steps, wherein a total distance of the plurality of phase steps is equal to or greater than a pitch magnitude of the first one of the gratings.

8. The method of claim 7 , wherein a second one of the gratings comprises a phase grating for generating an interference pattern of the x-ray beam after the x-ray beam has passed through the portion of the animal body, and wherein the pitch magnitude of the first one of the gratings is equivalent to the distance between peaks of the interference pattern.

9. The method of claim 8 , wherein the step of capturing the series of radiographic images comprises positioning the first grating behind the second grating and capturing the radiographic images immediately after the x-ray beam has passed through the first grating.

10. The method of claim 9 , wherein the pitch magnitude of the first grating is about half of a pitch magnitude of the second grating.

11. The method of claim 6 , wherein the step of phase stepping comprises repositioning the first one of the gratings in a direction perpendicular to a direction of the x-ray beam emitted by the x-ray source.

12. The method of claim 11 , further comprising determining a difference in material composition of the portion of the animal body based on the determined intensity of the captured radiographic images of the portion of the animal body.

13. The method of claim 12 , wherein the step of determining the difference in material composition comprises determining a phase shift across the captured radiographic images, wherein the pixel values each correspond to one data point of a sinusoidal shape of the interference pattern.

14. A method of determining material composition of a portion of an animal body, the method comprising:
capturing a series of digital radiographic images of the portion of the animal body using an x-ray beam emitted by an x-ray source;
determining an energy intensity of the captured radiographic images of the portion of the animal body;
determining a magnitude of an x-ray phase shift that occurred in the portion of the animal body using the captured radiographic images of the portion of the animal body;
generating a differential phase shift image of the portion of the animal body;
generating an integrated phase image of the portion of the animal body;
determining a difference in material composition of the portion of the animal body based on a combination of the determined energy intensity and the determined magnitude of the x-ray phase shift; and
generating and displaying a radiographic image of the portion of the animal body including separately displaying within the radiographic image of the portion of the animal body a first type soft tissue and a second type soft tissue inside the portion of the animal body using the differential phase shift image of the portion of the animal body and the integrated phase image of the portion of the animal body.

15. The method of claim 14 , wherein the step of generating and displaying the radiographic image of the portion of the animal body includes separately displaying within the radiographic image of the portion of the animal body two different non-bony soft tissues inside the portion of the animal body.

16. The method of claim 15 , wherein the step of generating and displaying a radiographic image of the portion of the animal body includes separately displaying within the radiographic image of the portion of the animal body glandular and adipose tissue inside the portion of the animal body.

17. The method of claim 14 , wherein the step of capturing comprises using a digital detector, the digital detector comprising a plurality of pixels, and wherein the steps of determining the energy intensity and determining the magnitude of the x-ray phase shift are performed for each pixel.

18. The method of claim 17 , wherein the step of capturing comprises positioning a plurality of gratings in a path of the x-ray beam and phase stepping only a first one of the gratings into a different position for capturing each of the radiographic images.

19. The method of claim 18 , wherein the step of phase stepping comprises repositioning the first one of the gratings an equal distance for each of the different positions, wherein a total distance of said repositioning the first one of the gratings for each of the different positions is equal to or greater than a pitch magnitude of the first one of the gratings.

20. The method of claim 19 , wherein a second one of the gratings comprises a phase grating for generating an interference pattern of the x-ray beam after the x-ray beam has passed through the portion of the animal body, and wherein the pitch magnitude of the first one of the gratings is equivalent to the distance between peaks of the interference pattern.

21. The method of claim 20 , wherein the step of capturing the series of radiographic images comprises positioning the first grating behind the second grating in relation to the x-ray source and capturing the radiographic images after the x-ray beam has passed through the first grating.

22. The method of claim 20 , wherein the pitch magnitude of the first grating is

Assignees

• Carestream Health Inc

Inventors

• Baturin Pavlo
• Shafer Mark E

Classifications

• A61B6/4291

  the detector being combined with a grid or grating · CPC title

• A61B6/484 Primary

  involving phase contrast X-ray imaging · CPC title

• A61B6/4233

  using matrix detectors · CPC title

• A61B6/4035

  the source being combined with a filter or grating · CPC title

• A61B6/461

  Displaying means of special interest · CPC title