Compositions and methods for increasing bone mineralization

Patent metadata

Field	Value
Publication number	US-9791462-B2
Application number	US-201514626274-A
Country	US
Kind code	B2
Filing date	Feb 19, 2015
Priority date	Nov 27, 1998
Publication date	Oct 17, 2017
Grant date	Oct 17, 2017

Abstract

A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

First claim

We claim:

1. A method for identifying a candidate molecule capable of inhibiting binding of a protein encoded by SEQ ID NO: 1 to bone or an analogue thereof, comprising: combining, in vitro, a candidate molecule and a protein encoded by SEQ ID NO: 1 in the presence of bone or an analogue thereof; and detecting whether the candidate molecule inhibits the binding of the protein to bone or an analogue thereof.

2. The method according to claim 1 , wherein said analogue of bone is hydroxyapatite.

Assignees

• Ucb Pharma Sa
• Ucb Pharma Sa

Inventors

• Brunkow Mary E
• Galas David J
• Kovacevich Brian
• Mulligan John T
• Paeper Bryan W
• Van Ness Jeffrey
• Winkler David G

Classifications

• G01N2500/20

  cell-free systems · CPC title

• C07K16/18

  against material from animals or humans · CPC title

• A01K2217/05

  Animals comprising random inserted nucleic acids (transgenic) · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title

• C12Q2600/156

  Polymorphic or mutational markers · CPC title