Microbiome identification and bacteriophage formulations
US-2024123002-A1 · Apr 18, 2024 · US
Assays for antimicrobial activity and applications thereof
US9791440B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9791440-B2 |
| Application number | US-201414904583-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 15, 2014 |
| Priority date | Jul 15, 2013 |
| Publication date | Oct 17, 2017 |
| Grant date | Oct 17, 2017 |
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- Title
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- Abstract
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Abstract
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The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of diagnosing a microbial infection in a subject, the method comprising: (i) assaying a biological sample from a subject for the presence of MAMPs with a PRR-based assay; and (ii) comparing the detectable signal level of MAMPs obtained from (i) to the level of MAMPs in a non-infected subject; and (iii) identifying the subject to be likely infected with at least one microbe if the detectable signal level of MAMPs is higher than the level of MAMPs in a non-infected subject; or identifying the subject to be unlikely infected with microbes if the detectable signal level is not higher than the level of MAMPs in a non-infected subject. 2. The method of claim 1 , wherein said at least one microbe has a masking capsule (encapsulated). 3. The method of claim 1 , wherein said at least one microbe is non-capsulated. 4. The method of claim 1 , wherein said at least one microbe is resistant to at least one antimicrobial agent. 5. The method of claim 1 , further comprising administering an antimicrobial treatment to the subject.
Assignees
Inventors
Classifications
Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis · CPC title
Mycobacteria · CPC title
Assays, e.g. immunoassays or enzyme assays, involving carbohydrates · CPC title
- G01N33/56911Primary
Bacteria · CPC title
Testing for antimicrobial activity of a material · CPC title
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Frequently asked questions
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- What does patent US9791440B2 cover?
- The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
- Who is the assignee on this patent?
- Harvard College
- What technology area does this patent fall under?
- Primary CPC classification G01N33/56911. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Oct 17 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).