Multi-target photonic biosensor, and method for manufacturing and preparing same

Patent metadata

Field	Value
Publication number	US-9791439-B2
Application number	US-201213983093-A
Country	US
Kind code	B2
Filing date	Feb 9, 2012
Priority date	Feb 9, 2011
Publication date	Oct 17, 2017
Grant date	Oct 17, 2017

Abstract

A component or device is provided for the detection or the measurement in parallel of one or more specific types of biological or chemical target products. This component includes a group of nanotubes selected and/or functionalized to interact with the target product, around an optical waveguide. Thus, an optical coupling is produced between the optical waveguide and one or more optical characteristics of these nanotubes, the modifications of which are evaluated in the presence of the target product. In addition, a method is provided for manufacturing and preparing such a component or device, and a detection method using them, as well as a post-manufacture preparation method comprising a specific functionalization for different target products starting from the same type of pluripotent generic component. Also provided is a family of PFO-based functionalization polymers.

First claim

The invention claimed is:

1. A component for detecting or measuring at least one specific type of biological or chemical product called a target product and supplying a light signal or electronic signal representing the presence of said target product in a biological or chemical medium to be tested, when said medium to be tested is brought into contact with a sensor, the component comprising:
at least one optical waveguide element associated with the sensor, wherein the operation of said at least one optical waveguide is modified by the presence of said target product in the medium to be tested;
one or more nanotubes configured to interact with said target product due to molecules called receptors which are chosen to specifically interact with or bind to said target product and are bound to said one or more nanotubes via molecules or chains of molecules of at least one polymer, called a functionalization polymer, bound to the surface of said one or more nanotubes one or more optical characteristics of said one or more nanotubes being modified by said functionalization polymer;
said one or more nanotubes surrounding said at least one optical waveguide element over at least part of its periphery and inducing an optical coupling in a coupling portion of said at least one optical waveguide, between:
an optical signal transmitted or received in said coupling portion of said at least one optical waveguide, and
one or more optical characteristics of said one or more nanotubes;

wherein the coupling portion is enclosed in or connected to an optical element that carries out an optical amplification or an optical detection of said modifications of the optical characteristics of the nanotubes; and
wherein detecting or measuring said at least one target product is provided through said detection of the modifications of the optical characteristics of the nanotubes.

2. The component according to claim 1 , wherein the functionalization polymer receives a plurality receptors, associated with different target products.

3. The component according to claim 1 , wherein the one or more nanotubes in the group are single-walled carbon nanotubes of semiconducting type.

4. The component according to claim 1 , wherein the coupling portion of the at least one optical waveguide is arranged to obtain an evanescent mode which confines the electromagnetic wave around at least some of the nanotubes.

5. The component according to claim 1 , wherein the at least one optical waveguide is made of silicon or silicon nitride.

6. The component according to claim 1 , wherein the coupling portion is enclosed in or connected to an optical element that carries out an optical amplification or an optical detection of the modifications of the optical characteristics of the nanotubes originating from the interaction with the target product.

7. The component according to claim 1 , wherein the at least one optical waveguide is produced on a base or a substrate by a photonic or optronic circuit manufacturing procedure.

8. A device for detecting at least one specific type of biological or chemical product called target, for example in liquid or gaseous form, comprising: a plurality of sensors each including at least one component according to claim 1 arranged so as to interact simultaneously and independently of each other with the same medium to be tested.

9. The device according to claim 8 , characterized in that at least two of the sensors are functionalized in order to detect or measure two different target products.

10. The method for detecting or measuring at least one specific type of biological or chemical product called a target, comprising a use of the component according to claim 1 .

11. The method for detecting or measuring a plurality of different types of biological or chemical products called a target, for example in liquid or gaseous form, comprising a use of a device according to claim 8 .

Assignees

• Vivien Laurent
• Gaufres Etienne
• Izard Nicolas
• Doris Eric
• Gravel Edmond
• Boquet Didier
• Univ Paris Sud 11
• Centre Nat Rech Scient
• Commissariat Energie Atomique

Inventors

• Vivien Laurent
• Gaufres Etienne
• Izard Nicolas
• Doris Eric
• Gravel Edmond
• Boquet Didier

Classifications

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• G01N2021/7789

  Cavity or resonator · CPC title

• G01N2021/7776

  Index · CPC title

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title

• G01N21/45 Primary

  using interferometric methods; using Schlieren methods · CPC title