Heterocyclic compounds

Patent metadata

Field	Value
Publication number	US-9790187-B2
Application number	US-201514791611-A
Country	US
Kind code	B2
Filing date	Jul 6, 2015
Priority date	Aug 29, 2011
Publication date	Oct 17, 2017
Grant date	Oct 17, 2017

Abstract

Described herein are methods for synthesizing heterocyclic, 8-membered ring structures. The methods may allow for preparation of highly substituted 8-membered rings. Also disclosed are heterocyclic, 8-membered ring compounds and pharmaceutical compositions comprising the compounds.

First claim

The invention claimed is:

1. A compound of formula (I):

wherein:
X is selected from the group consisting of O and NR 1 ;
R 1 is selected from the group consisting of hydrogen and a nitrogen protecting group;
R 2 is selected from the group consisting of —C(O)O—, —C(O)—, —O—, —NR 4 — and —CR 5 2 —;
each R 3 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl and cyano, any of which is optionally substituted;
R 4 is selected from the group consisting of hydrogen, alkyl, and a nitrogen protecting group; and
each R 5 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, acyl, alkoxy, amido, amino, carboxy, cyano, ester, halo, haloalkyl, hydroxy, nitro, phosphonate, sulfinyl, sulfonyl, sulfonate, sulfonamino and sulfonamido, any of which is optionally substituted; or two R 5 are taken together with the atom to which they are attached to form an optionally substituted ring system.

2. A pharmaceutical composition comprising a compound according to claim 1 .

3. The compound of claim 1 , wherein the nitrogen protecting group is an alkyl.

Assignees

• Univ Utah Res Found

Inventors

• Louie Janis
• Kumar Puneet

Classifications

• C07D491/113

  with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring · CPC title

• C07D491/04

  Ortho-condensed systems · CPC title

• C07D487/04

  Ortho-condensed systems · CPC title

• C07D225/04 Primary

  condensed with carbocyclic rings or ring systems · CPC title

• C07D313/20

  condensed with carbocyclic rings or ring systems · CPC title