Deamorphization of spray-dried formulations via spray-blending
US-2015374623-A1 · Dec 31, 2015 · US
US9789269B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9789269-B2 |
| Application number | US-201113703197-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 9, 2011 |
| Priority date | Jun 11, 2010 |
| Publication date | Oct 17, 2017 |
| Grant date | Oct 17, 2017 |
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A fluid dispenser device comprising: a dose counter for indicating the number of doses that have been dispensed or that remain to be dispensed, said counter comprising: at least one rotary counter element provided with indicator means, such as digits or numbers, and provided with a first set of teeth and with a second set of teeth; a movable actuator element adapted to co-operate with said first set of teeth of said counter element so as to turn it; and anti-return means adapted to co-operate with said second set of teeth so as to prevent said counter element from turning in the direction opposite to the direction that is imposed by said actuator element; said anti-return means comprising a tip that is substantially V-shaped, and that, after each actuation of the counter, co-operates with a respective tooth of said second set of teeth in a blocking position, said tip comprising a first branch that is adapted to co-operate in the blocking position with a blocking shoulder of said tooth, and a second branch that is plane and adapted to co-operate with a plane surface of said teeth, said plane second branch and said plane surface being coplanar when said tip is in the blocking position, said tip being urged resiliently towards said blocking position so as to ensure accurate positioning of said counter element after each actuation of the counter.
Opening claim text (preview).
The invention claimed is: 1. A fluid dispenser device comprising: a body provided with a dispenser orifice; a plurality of individual reservoirs each containing one dose of powder; dispenser means for dispensing one dose of powder on each actuation, said dispenser means including reservoir opening means for opening a respective reservoir on each actuation and for releasing the dose of powder; and a dose counter for indicating the number of doses that have been dispensed or that remain to be dispensed, said counter comprising: at least one rotary counter element provided with indicator means, and provided with a first set of teeth and with a second set of teeth; a movable actuator element adapted to co-operate with said first set of teeth of said counter element so as to turn said counter element; and anti-return means adapted to co-operate with said second set of teeth so as to prevent said counter element from turning in the direction opposite to the direction that is imposed by said actuator element; wherein said anti-return means comprise a tip that is substantially V-shaped, and that, after each actuation of the counter, co-operates with a respective tooth of said second set of teeth in a blocking position, said tip comprising a first branch that is adapted to cooperate in the blocking position with a blocking shoulder of said tooth, and a second branch that is plane and adapted to co-operate with a plane surface of said teeth, said plane second branch and said plane surface being coplanar when said tip is in the blocking position, said tip being urged resiliently towards said blocking position so as to ensure accurate positioning of said counter element after each actuation of the counter; wherein said anti-return means are substantially S-shaped, with a first loop providing springiness, and a second loop forming the tip; and wherein ends of the S-shape are connected to a stationary portion of said body; and wherein the first loop of the S-shape elastically deforms upon actuation of the dispenser during which opposing segments of the first loop are squeezed bringing the opposing segments into closer proximity to each other. 2. The device according to claim 1 , wherein, on each actuation of the counter, turning of the counter element is primarily due to the actuator element, said tip contributing to a final portion of said turning. 3. The device according to claim 1 , wherein the indicator means are digits or numbers. 4. A fluid dispenser device comprising: a body provided with a dispenser orifice; a plurality of individual reservoirs each containing one dose of powder that is released on each actuation of the dispenser and dispensed through the dispenser orifice; and a dose counter for indicating the number of doses that have been dispensed or that remain to be dispensed, the dose counter comprises: at least one rotary counter element provided with indications and with a first set of teeth and a second set of teeth; a movable actuator adapted to co-operate with the first set of teeth so as to turn the counter element; and an anti-return mechanism adapted to co-operate with the second set of teeth so as to prevent the counter element from turning in a direction opposite to a direction that is imposed by the actuator element; wherein the anti-return mechanism comprises a tip that is substantially V-shaped, and that, after each actuation of the rotary counter, co-operates with a respective tooth of the second set of teeth in a blocking position, the tip comprising a first branch that is adapted to cooperate in the blocking position with a corresponding blocking shoulder of the tooth, and a second branch that is adapted to be flush with a surface of the teeth when the tip is in the blocking position, the tip being urged resiliently towards the blocking position so as to ensure accurate positioning of the counter element after each actuation of the counter element; and wherein the anti-return mechanism is substantially S-shaped, with a first loop providing springiness, and a second loop forming the tip; wherein ends of the S-shape are connected to a stationary portion of the body; and wherein the first loop of the S-shape elastically deforms upon actuation of the rotary counter during which opposing segments of the first loop that form half of the S-shape elastically compress bringing the opposing segments closer together. 5. The device according to claim 4 , wherein the second branch is planar and the surface of the teeth is coplanar when the second branch is flush with the surface. 6. The device according to claim 5 , wherein the first branch is curved. 7. The device according to claim 4 , wherein the S-shape is deformable radially with respect to the rotary counter element.
on a disc · CPC title
with fixed piercing or cutting means · CPC title
Powder · CPC title
Hindering inhalation before activation of the dispenser · CPC title
the used dosages being coiled · CPC title
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