Synthesis of adansonia digitata nanoparticles

Patent metadata

Field	Value
Publication number	US-9789146-B1
Application number	US-201715452688-A
Country	US
Kind code	B1
Filing date	Mar 7, 2017
Priority date	Mar 7, 2017
Publication date	Oct 17, 2017
Grant date	Oct 17, 2017

Abstract

A method of preparing Adansonia digitata nanoparticles includes dissolving Adansonia digitata plant powder in an organic solvent to form a solution; spraying the solution in boiling water while applying ultrasonic energy to form a mixture; and stirring the mixture for at least about 15 minutes at a speed of about 200-800 rpm to obtain the Adansonia digitata nanoparticles.

First claim

We claim:

1. A method of synthesizing Adansonia digitata nanoparticles, comprising:
dissolving Adansonia digitata plant powder in an organic solvent selected from the group consisting of at least one of methanol, ethanol, dichloromethane, and chloroform to form a solution;
adding about 1 ml to about 4 ml of the solution to about 50 ml to about 100 ml of boiling water under ultrasonic conditions to form a mixture; and;
stirring the mixture at a speed of about 200 rpm to about 800 rpm to obtain Adansonia digitata nanoparticles,

wherein the ultrasonic conditions include sonication for about 10 minutes to about 20 minutes with an ultrasonic power of 100 W and a frequency of 30 kHz prior to being stirred, and
wherein the Adansonia digitata nanoparticles have a mean diameter in the range of from about 50 nm to about 300 nm.

2. The method of synthesizing Adansonia digitata nanoparticles according to claim 1 , further comprising isolating and drying the Adansonia digitata nanoparticles to obtain dried Adansonia digitata nanoparticle powder.

3. The method of synthesizing Adansonia digitata nanoparticles according to claim 1 , wherein the Adansonia digitata plant powder is derived from the fruit pulp of Adansonia digitata.

4. The method of preparing Adansonia digitata nanoparticles according to claim 1 , wherein the solution is added to the boiling water by spraying the solution dropwise into the boiling water at a rate of about 0.2 ml/minute in about 5 minutes.

5. The method of synthesizing Adansonia digitata nanoparticles according to claim 1 , wherein the Adansonia digitata nanoparticles have spherical, spheroidal, elongated, spherical, rod-shaped, and/or faceted shapes.

Assignees

• Univ King Saud

Inventors

• Awad Manal Ahmed Gasmelseed
• Hendi Awatif Ahmed
• Ortashi Khalid Mustafa Osman

Classifications

• A61K36/577 Primary

  Malvaceae (Mallow family) · CPC title

• A61K9/5192

  Processes · CPC title

• A61K9/5138

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates · CPC title

• A61K2236/51

  Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying · CPC title

• A61K2236/39

  Complex extraction schemes, e.g. fractionation or repeated extraction steps · CPC title