Process for preparing pemetrexed di potassium and its hydrates
US-2015259348-A1 · Sep 17, 2015 · US
US9789113B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9789113-B2 |
| Application number | US-201515310451-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 23, 2015 |
| Priority date | Jun 30, 2014 |
| Publication date | Oct 17, 2017 |
| Grant date | Oct 17, 2017 |
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The present application provides pharmaceutical compositions derived from pemetrexed dipotassium Nonahydrate and its process thereof. The present application also provides a method of treating cancer by administering intravenously the reconstituted lyophilized compositions into a patient in need thereof.
Opening claim text (preview).
The invention claimed is: 1. A pharmaceutical composition comprising pemetrexed dipotassium nonahydrate characterized by X-ray powder diffraction pattern containing at least 5 characteristic 2θ° diffraction angle peaks selected from the XRPD peak set of 5.0, 12.5, 17.2, 20.8, 22.4, 25.7, 26.9 and 27.9±0.20 2θ°, and a pharmaceutically acceptable amount of an excipient, wherein the pharmaceutical composition having moisture content less than 2% w/w.
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Ortho-condensed systems · CPC title
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title
lyophilised {, i.e. freeze-dried, solutions or dispersions (lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00)} · CPC title
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