Nitrogen-containing heterocyclic compound

Patent metadata

Field	Value
Publication number	US-9789084-B2
Application number	US-201715608565-A
Country	US
Kind code	B2
Filing date	May 30, 2017
Priority date	Apr 23, 2014
Publication date	Oct 17, 2017
Grant date	Oct 17, 2017

Abstract

The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.
The present invention relates to a compound represented by the formula (I) or a salt thereof.

wherein each symbol is as described in the specification,

or a salt thereof.

First claim

The invention claimed is:

1. A method for the treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia or dementia with Lewy bodies in a mammal, which comprises administering to the mammal an effective amount of 2-((1S,2S)-2-hydroxycyclohexyl)-4,5-dimethyl-6-((6-methylpyridin-3-yl)methyl)isoindolin-1-one or a salt thereof,
in combination with an effective amount of one or more other active ingredients selected from donepezil, galanthamine, mematine and rivastigmine.

2. The method of claim 1 , wherein the other active ingredient is donepezil.

3. The method of claim 1 , wherein the other active ingredient is galanthamine.

4. The method of claim 1 , wherein the other active ingredient is memantine.

5. The method of claim 1 , wherein the other active ingredient is rivastigmine.

Assignees

• Takeda Pharmaceuticals Co

Inventors

• Yamada Masami
• Suzuki Shinkichi
• Sugimoto Takahiro
• Nakamura Minoru
• Sakamoto Hiroki
• Kamata Makoto

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/20

  Hypnotics; Sedatives · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/24

  Antidepressants · CPC title