Analyte sensing biointerface

Patent metadata

Field	Value
Publication number	US-9788766-B2
Application number	US-201414281697-A
Country	US
Kind code	B2
Filing date	May 19, 2014
Priority date	Apr 15, 2005
Publication date	Oct 17, 2017
Grant date	Oct 17, 2017

Abstract

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

First claim

What is claimed is:

1. A transcutaneous continuous glucose sensor system, comprising:
a substantially planar sensor, the sensor comprising:
a first non-conductive layer;
a first conductive layer comprising a first electrode, wherein the first conductive layer is disposed over the first non-conductive layer;
a second non-conductive layer disposed over the first conductive layer;
a second conductive layer comprising a second electrode, wherein the second conductive layer is disposed over the second non-conductive layer;
a third non-conductive layer disposed over the second conductive layer;
a third conductive layer comprising a third electrode, wherein the third conductive layer is disposed over the third non-conductive layer;
wherein at least one of the first electrode, second electrode, or third electrode is a working electrode configured to measure a signal indicative of a glucose concentration;

a membrane disposed on at least a portion of the sensor; and
electronics electrically coupled to the working electrode.

2. The sensor of claim 1 , wherein the membrane comprises an enzyme.

3. The sensor of claim 2 , wherein the membrane further comprises a resistance domain disposed over the enzyme.

4. The sensor of claim 1 , wherein the membrane further comprises a bioactive agent.

5. The sensor of claim 1 , wherein the membrane is substantially planar.

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Brauker James H

Classifications

• B33Y80/00

  Products made by additive manufacturing · CPC title

• A61B5/0031

  Implanted circuitry · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• C12Q1/006

  for glucose · CPC title

• C12Q1/001

  Enzyme electrodes · CPC title