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US9783858B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9783858-B2 |
| Application number | US-201514677239-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 2, 2015 |
| Priority date | Apr 2, 2014 |
| Publication date | Oct 10, 2017 |
| Grant date | Oct 10, 2017 |
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Abstract
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Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ).
First claim
Opening claim text (preview).
We claim: 1. A method comprising: testing, or having tested a stool sample from a subject suspected of suffering from interstitial cystitis (IC), to determine the level of bacteria from at least one bacterial species from a bacterial genus, wherein said bacterial genus is selected from the group consisting of: Odoribacter, Faecalibacterium, Colinsella, Eggerthella, Lactonifactor , and Roseburia. 2. The method of claim 1 , wherein said at least one species is selected from the group consisting of: Odoribacter splanchnicus, Faecalibacterium prausnitzii, Colinsella aerofaciens, Eggerthella sinensis, Lactonifactor longoviformis , and Roseburia intestinalis. 3. The method of claim 1 , wherein said at least one species is at least two species selected from the group consisting of: Odoribacter splanchnicus, Faecalibacterium prausnitzii, Colinsella aerofaciens, Eggerthella sinensis, Lactonifactor longoviformis , and Roseburia intestinalis. 4. The method of claim 1 , wherein said at least one species is at least five species selected from the group consisting of: Odoribacter splanchnicus, Faecalibacterium prausnitzii, Colinsella aerofaciens, Eggerthella sinensis, Lactonifactor longoviformis , and Roseburia intestinalis. 5. The method of claim 1 , wherein said stool sample is tested with a sequencing assay specific to ribosomal RNA of said at least one species. 6. The method of claim 1 , further comprising comparing the level of bacteria to healthy control population levels.
Assignees
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Classifications
Bacteria (therapeutic use of a bacterial protein A61K38/00) · CPC title
- C12Q1/689Primary
for bacteria · CPC title
Probiotics · CPC title
for diseases caused by alterations of genetic material · CPC title
Probiotics (probiotic yeast, e.g. saccharomyces A61K36/06) · CPC title
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- What does patent US9783858B2 cover?
- Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and/or interstitial cystitis/bladder pain syndrome (IC/BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis , and R. intestinalis ). In certain embodiments, then present in…
- Who is the assignee on this patent?
- Univ Northwestern, Univ Illinois, Board Of Trustees Of The Univ Of Illinois
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/689. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 10 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).