Catecholamine-based versatility film and a preparation method thereof

Patent metadata

Field	Value
Publication number	US-9783837-B2
Application number	US-201514735456-A
Country	US
Kind code	B2
Filing date	Jun 10, 2015
Priority date	Jun 17, 2014
Publication date	Oct 10, 2017
Grant date	Oct 10, 2017

Abstract

The present invention relates to a method for preparing a double-sided film containing the step of 5 forming a film in the interface between air and the mixture of a polymer comprising amine group (—NH) and a compound containing phenol or catechol by exposing the mixture on the air. Particularly, the double-sided film of the present invention is a separation membrane 10 that can separate the interface of liquid phase and gas phase and at the same time can be used as a biomaterial such as a haemostatic and also an waterproof agent. When the film is prepared in a moderate condition by using an enzyme, the film can include proteins and 15 cells, resulting in the multi-functional versatility film that can be useful as a biocatalyst. The versatility film of the present invention, thus, is not expensive and the production method thereof is simple and eco-friendly.

First claim

What is claimed is:

1. A method for preparing a double-sided film comprising:
(a) mixing a polymer comprising an amine group (—NH) and a compound comprising a phenol or catechol group to form a mixture; and
(b) exposing the mixture to air to form the double-sided film in an interface between the air and the mixture,
wherein the film is formed by a difference of catechol oxidation between the interface and an interior of the mixture.

2. The method for preparing a double-sided film according to claim 1 , wherein the polymer is selected from the group consisting of polyacrylamide, polyethylenimine, polyamine, polyamideamine, and chitosan.

3. The method for preparing a double-sided film according to claim 1 , wherein the compound comprising the phenol or catechol group is selected from the group consisting of L-tyrosine, L-dopa, pyrogallol, dopamine, pyrocatechol, norepinephrine, and 3,4-dihydroxycinnamic acid (DHCA).

4. The method for preparing a double-sided film according to claim 1 , wherein the mixture is prepared by mixing an aqueous solution comprising a polymer comprising an amine group (10˜50 weight part) and an aqueous solution comprising a compound comprising a phenol or catechol group (1˜5 weight part) at a volume ratio of 1:1.

5. The method for preparing a double-sided film according to claim 1 , wherein the pH of the mixture is 5˜14.

6. The method for preparing a double-sided film according to claim 1 , wherein the both sides of the double-sided film have different strength and chemical composition from each other.

7. The method for preparing a double-sided film according to claim 1 , further comprising fixing silver nanoparticles by treating an aqueous solution containing silver ions after forming the film in the interface between air and the mixture.

8. The method for preparing a double-sided film according to claim 7 , wherein the silver ions were reduced into silver nanoparticles by the oxidation/reduction of catechol, so that the silver ions were fixed on the film.

9. The method for preparing a double-sided film according to claim 1 , wherein the mixture further comprises tyrosinase.

10. A double-sided film prepared by a method of:
(a) mixing a polymer comprising an amine group and a compound comprising a phenol or catechol group to form a mixture; and
(b) exposing the mixture to air to form the double-sided film in an interface between the air and the mixture,
wherein the film is formed by a difference of catechol oxidation between the interface and an interior of the mixture.

11. A method for preparing a double-sided film, comprising forming a film by exposing a mixture of a polymer comprising a phenol group and tyrosinase to air.

12. The method for preparing a double-sided film according to claim 11 , wherein the mixture further comprises a compound comprising a phenol or catechol group.

13. A double-sided film prepared by exposing a mixture of a compound comprising a phenol group and tyrosinase to air.

Assignees

• Korea Advanced Inst Sci & Tech
• Korea Advanced Inst Of Science Of Tech

Inventors

• Lee Hae Shin
• Hong Seon Ki
• Park Joseph Paul

Classifications

• C12P13/02

  Amides, e.g. chloramphenicol {or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes (peptides C12P21/00 or C07K)} · CPC title

• C08K3/08

  Metals · CPC title

• C08J2379/02

  Polyamines · CPC title

• C08K2201/013

  Additives applied to the surface of polymers or polymer particles · CPC title

• C08J5/18 Primary

  Manufacture of films or sheets · CPC title