Nitrogen-containing heterocyclic compound or salt thereof

Patent metadata

Field	Value
Publication number	US-9783536-B2
Application number	US-201514795568-A
Country	US
Kind code	B2
Filing date	Jul 9, 2015
Priority date	Jan 11, 2013
Publication date	Oct 10, 2017
Grant date	Oct 10, 2017

Abstract

A compound represented by Formula [1](in the formula, Z 1 represents N, CH, or the like; X 1 represents NH or the like; R 1 represents a heteroaryl group or the like; each of R 2 , R 3 , and R 4 represents a hydrogen atom, a halogen atom, an alkoxy group, or the like; and R 5 represents a heteroaryl group or the like) or salt thereof.

First claim

What is claimed is:

1. A nitrogen-containing heterocyclic compound represented by the following Formula [1]or salt thereof:

wherein, in Formula [1]:
Z 1 represents N or CR 6d ;
R 6d represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group which may be substituted, a C 1-6 alkoxy group which may be substituted, or NHR 8d ;
R 8d represents a hydrogen atom or a C 1-6 alkyl group which may be substituted;
X 1 represents NR 9 or S;
R 9 represents a hydrogen atom, a C 1-6 alkyl group which may be substituted, or an amino protecting group;
R 1 represents a monocyclic nitrogen-containing heteroaryl group which may be substituted, a monocyclic nitrogen- and oxygen-containing heteroaryl group which may be substituted, a monocyclic nitrogen- and sulfur-containing heteroaryl group which may be substituted, a bicyclic nitrogen-containing heteroaryl group which may be substituted, a bicyclic nitrogen- and oxygen-containing heteroaryl group which may be substituted, or a bicyclic nitrogen- and sulfur-containing heteroaryl group which may be substituted;
R 2 represents a hydrogen atom or a halogen atom;
R 3 represents a hydrogen atom or a halogen atom;
R 4 represents a hydrogen atom, a halogen atom, an amino group which may be protected, a hydroxyl group which may be protected, a C 1-6 alkyl group which may be substituted, or a C 1-6 alkoxy group which may be substituted;
R 5 represents a C 3-8 cycloalkyl group which may be substituted, an aryl group which may be substituted, a heteroaryl group which may be substituted, a heterocyclyl group which may be substituted, or NR 12a R 13a , provided that in a case in which Z 1 represents N and R 4 represents a hydrogen atom, R 5 represents a C 3-8 cycloalkyl group which may be substituted, a heteroaryl group which may be substituted, a heterocyclyl group which may be substituted, or NR 12a R 13a ;
R 12a presents a hydrogen atom or a C 1-6 alkyl group which may be substituted; and
R 13a represents a C 3-8 cycloalkyl group which may be substituted, an aryl group which may be substituted, a heteroaryl group which may be substituted, or a heterocyclyl group which may be substituted.

2. The nitrogen-containing heterocyclic compound or salt thereof according to claim 1 , wherein R 4 represents a hydrogen atom, a halogen atom, an amino group which may be protected, or a C 1-6 alkoxy group which may be substituted.

3. The nitrogen-containing heterocyclic compound or salt thereof according to claim 1 , wherein:
Z 1 represents CR 6d ; and
R 6d has the same meaning as in claim 1 .

4. The nitrogen-containing heterocyclic compound or salt thereof according to claim 1 , wherein R 2 is a hydrogen atom.

5. The nitrogen-containing heterocyclic compound or salt thereof according to claim 1 , wherein R 3 is a hydrogen atom.

6. The nitrogen-containing heterocyclic compound or salt thereof according to claim 1 , wherein X 1 represents NR 9a or S, and R 9a represents a hydrogen atom or an amino protecting group.

7. The nitrogen-containing heterocyclic compound or salt thereof according to claim 1 , wherein R 1 represents a pyrazolyl group which may be substituted, an imidazolyl group which may be substituted, a triazolyl group which may be substituted, a thiazolyl group which may be substituted, an oxadiazolyl group which may be substituted, a thiadiazolyl group which may be substituted, a pyridyl group which may be substituted, or a pyridazinyl group which may be substituted.

8. The nitrogen-containing heterocyclic compound or salt thereof according to claim 1 , wherein:
R 1 represents a pyrazolyl group which may be substituted with one or more substituents selected from a substituent group A 1 , an imidazolyl group which may be substituted with one or more substituents selected from the substituent group A 1 , a triazolyl group which may be substituted with one or more substituents selected from the substituent group A 1 , a thiazolyl group which may be substituted with one or more substituents selected from the substituent group A 1 , an oxadiazolyl group which may be substituted with one or more substituents selected from the substituent group A 1 , a thiadiazolyl group which may be substituted with one or more substituents selected from the substituent group A 1 , a pyridyl group which may be substituted with one or more substituents selected from the substituent group A 1 , or a pyridazinyl group which may be substituted with one or more substituents selected from the substituent group A 1 ;
the substituent group A 1 consists of a halogen atom, a hydroxyl group which may be protected, an amino group which may be protected, a carboxyl group which may be protected, a cyano group, a carbamoyl group which may be substituted with one or more substituents selected from a substituent group B 1 , a sulfamoyl group which may be substituted with one or more substituents selected from the substituent group B 1 , a C 1-6 alkyl group which may be substituted with one or more substituents selected from the substituent group B 1 , a C 2-6 alkenyl group which may be substituted with one or more substituents selected from the substituent group B 1 , a C 3-8 cycloalkyl group which may be substituted with one or more substituents selected from the substituent group B 1 , an aryl group which may be substituted with one or more substituents selected from the substituent group B 1 , a C 1-6 alkoxy group which may be substituted with one or more substituents selected from the substituent group B 1 , a C 3-8 cycloalkoxy group which may be substituted with one or more substituents selected from the substituent group B 1 , an aryloxy group which may be substituted with one or more substituents selected from the substituent group B 1 , a C 1-6 alkylthio group which may be substituted with one or more substituents selected from the substituent group B 1 , an arylthio group which may be substituted with one or more substituents selected from the substituent group B 1 , a C 1-6 alkylamino group which may be substituted with one or more substituents selected from the substituent group B 1 , a di(C 1-6 alkyl)amino group which may be substituted with one or more substituents selected from the substituent group B 1 , an acyl group which may be substituted with one or more substituents selected from the substituent group B 1 , a heteroaryl group which may be substituted with one or more substituents selected from the substituent group B 1 , a heterocyclyl group which may be substituted with one or more substituents selected from the substituent group B 1 , and an oxo group;
the substituent group B 1 consists of a halogen atom, a hydroxyl group which may be protected, an amino group which may be protected, a carboxyl group which may be protected, a cyano group, a carbamoyl group which may be substituted with one or more substituents selected from a substituent group C 1 , a sulfamoyl group which may be substituted with one or more substituents selected from the substituent group C 1 , a C 1-6 alkyl group which may be substituted with one or more substituents selected from the substituent group C 1 , a C 3-8 cycloalkyl group which may be substituted with one or more substituents selected from the substituent group C 1 , an aryl group which may be substituted with one or more substituents selected from the substituent group C 1 , a C 1-6 alkoxy group which may be substituted with one or more substituents selected from the substituent group C 1 , a C 1-6 alkylamino group which may be substituted with one or more substit

Assignees

• Fujifilm Corp

Inventors

• Furuyama Hidetomo
• Kurihara Hideki
• Terao Takahiro
• Nakagawa Daisuke
• Tanabe Shintaro
• Kato Takayuki
• Yamamoto Masahiko
• Sekine Shinichiro
• Mashiko Tomoyuki
• INUKI Shinsuke
• Ueda Satoshi

Classifications

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P5/00

  Drugs for disorders of the endocrine system · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title