Medical device films

Patent metadata

Field	Value
Publication number	US-9782957-B2
Application number	US-201213589222-A
Country	US
Kind code	B2
Filing date	Aug 20, 2012
Priority date	Aug 24, 2011
Publication date	Oct 10, 2017
Grant date	Oct 10, 2017

Abstract

Medical devices described herein include a melt-pressed film having first and second diffusion barrier layers disposed thereon. The melt-pressed film and the barrier layers comprise bioabsorbable copolymers. In a further aspect, a therapeutic agent, such as an analgesic is included in the medical device.

First claim

What we claim is:

1. A medical device comprising:
a first spray coated diffusion barrier layer,
a second spray coated diffusion barrier layer, and
a melt-pressed film comprising a therapeutic agent disposed therebetween.

2. The medical device of claim 1 , wherein the melt-pressed film comprises a material selected from the group consisting of homopolymers and copolymers of lactide; glycolide; epsilon-caprolactone, p-dioxanone; trimethylene carbonate; alkyl derivatives of trimethylene carbonate; Δ-valerolactone; β-butyrolactone; γ-butyrolactone; ε-decalactone; hydroxybutyrate; hydroxyvalerate; 1,4-dioxepan-2-one; 1,5-dioxepan-2-one; 6,6-dimethyl- 1,4-dioxan-2-one; 2,5-diketomorpholine; pivalolactone; α, α diethylpropiolactone; ethylene carbonate; ethylene oxalate; 3-methyl-1,4-dioxane-2,5-dione; 3,3-diethyl-1,4-dioxan-2,5-dione; and 6,8-dioxabicycloctane-7-one.

3. The medical device of claim 2 , wherein the melt-pressed film comprises glycolide, trimethylene carbonate, epsilon-caprolactone, and lactide.

4. The medical device of claim 2 , wherein the melt-pressed film comprises a random copolymer.

5. The medical device of claim 1 , wherein at least the first or the second diffusion barrier layer comprises a biodegradable material.

6. The medical device of claim 1 , wherein at least the first or second diffusion barrier layer comprises glycolide and caprolactone.

7. The medical device of claim 1 , wherein at least the first diffusion barrier layer or the second diffusion barrier layer is from about 1 micron to about 50 microns thick.

8. The medical device of claim 1 , wherein the melt-pressed film is from about 1 millimeter to about 10 millimeters thick.

9. The medical device of claim 1 , wherein the therapeutic agent is selected from the group consisting of anti-adhesives, antimicrobials, analgesics, and, anesthetics.

10. The medical device of claim 1 , wherein the therapeutic agent is bupivacaine.

11. The medical device of claim 10 , wherein the therapeutic agent is at a concentration of from about 30% to about 50% of the melt-pressed film.

12. A medical device comprising:
a copolymer film including about 69% glycolide, about 7% trimethylene carbonate, about 17% caprolactone, about 7% lactide;
wherein the copolymer film is disposed between a first and second barrier layer; and,
at least one of the first and second barrier layers includes about 90% caprolactone and about 10% glycolide.

13. The medical device according to claim 12 , wherein the copolymer film includes a therapeutic agent at a concentration of from about 40% by weight to about 50% by weight.

Assignees

• Reinprecht Jon T
• Gleiman Seth
• Elachchabi Amin
• Witherell Ryan
• Stopek Joshua
• Ebersole Garrett
• Covidien Lp

Inventors

• Reinprecht Jon T
• Gleiman Seth
• Elachchabi Amin
• Witherell Ryan
• Stopek Joshua
• Ebersole Garrett

Classifications

• B32B2250/244

  All polymers belonging to those covered by group B32B27/36 · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• B32B2307/7163

  Biodegradable · CPC title

• B32B27/08

  of synthetic resin · CPC title

• A61L2300/402

  Anaestetics, analgesics, e.g. lidocaine · CPC title