Inductive magnetoelectric biochemical reaction system and application thereof

Patent metadata

Field	Value
Publication number	US-9782742-B2
Application number	US-201515107064-A
Country	US
Kind code	B2
Filing date	Mar 26, 2015
Priority date	Mar 18, 2015
Publication date	Oct 10, 2017
Grant date	Oct 10, 2017

Abstract

An inductive magnetoelectric biochemical reaction system includes a reaction unit which includes a reaction chamber, which includes a reactant container and is disposed in a rotatable perpendicular magnetic field; a primary coil, which is wound around one side of a closed-loop iron core and is connected to a control unit; a secondary coil, which is wound around the other side of the closed-loop iron core and includes an insulating tube which allows a reaction solution acting as a conductor, two ends of the insulating tube being communicated with the reactant container; a rotating magnetic field unit, which is configured to generate the rotatable perpendicular magnetic field; and a control unit, which is at least configured to adjust an excitation voltage and a signal type applied on the primary coil.

First claim

What is claimed is:

1. An inductive magnetoelectric biochemical reaction system, comprising:
a reaction unit, comprising:
a reaction chamber, which comprises a reactant container and is disposed in a rotatable radial magnetic field;
a primary coil, which is wound around one side of a closed-loop iron core and is connected to a control unit;
a secondary coil, which is wound around the other side of the closed-loop iron core and comprises an insulating tube which allows a reaction solution acting as a conductor, two ends of the insulating tube being communicated with the reactant container;
a rotatable magnetic field unit, which is configured to generate the rotatable radial magnetic field; and
a control unit, which is at least configured to adjust an excitation voltage of various signal waveforms applied on the primary coil
and the control unit comprises a function signal generator, an output terminal of the function signal generator being connected to an input terminal of a power amplifier, an output terminal of the power amplifier being connected to the primary coil, wherein the function signal generator is capable of generating an AC signal having a frequency range of 50 to 200 Hz and a voltage level of 10 to 20 Vp-p, the AC signal comprising a sine wave, a triangular wave, a sawtooth wave, a unidirectional square wave, a bidirectional square wave, or a customized function signal, and the power amplifier has a power of 80 to 200 VA, an output AC voltage level of 200 to 400 Vp-p, and a full-power frequency width of 50 to 200 Hz.

2. The inductive magnetoelectric biochemical reaction system according to claim 1 , wherein the rotatable magnetic field unit comprises two arc permanent magnets which are fixedly arranged in an annular shape with heteropolars oppositely disposed, a radian of either of the two arc permanent magnets being less than 180 degrees; and a driving mechanism configured to drive the two arc permanent magnets to rotate.

3. The inductive magnetoelectric biochemical reaction system according to claim 2 , wherein the arc permanent magnet has a central magnetic flux density of 2000 to 3000 Gs.

4. The inductive magnetoelectric biochemical reaction system according to claim 1 , wherein the rotatable magnetic field unit further comprises a detachable iron yoke cylinder, two arc permanent magnets are fixedly arranged in an annular shape on an inner wall of the iron yoke cylinder, and the iron yoke cylinder is connected to a driving mechanism based on transmission, wherein the driving mechanism is configured to drive the two arc permanent magnets to rotate.

5. The inductive magnetoelectric biochemical reaction system according to claim 4 , wherein the driving mechanism comprises a servo motor controlled by a servo motor controller which is connected to the iron yoke cylinder.

6. The inductive magnetoelectric biochemical reaction system according to claim 1 , wherein the reaction unit further comprises a temperature control unit, configured to control the temperature in the reactant container to −20 to 100° C.

7. The inductive magnetoelectric biochemical reaction system according to claim 6 , wherein the temperature control unit comprises a constant temperature circulating water bath which is communicated with a water inlet and a water outlet of a jacket layer on the reaction chamber.

8. The inductive magnetoelectric biochemical reaction system according to claim 1 , wherein the primary coil is a single-strand copper wire having a diameter of 6 to 8 mm and having 20 to 26 turns.

9. The inductive magnetoelectric biochemical reaction system according to claim 1 , wherein the secondary coil comprises a glass spiral tube having an inner diameter of 2 to 3 mm, having 10 to 13 turns, and having a total length of 700 to 900 mm.

10. The inductive magnetoelectric biochemical reaction system according to claim 1 , wherein the closed-loop iron core is made of a silicon steel material and works in a frequency range of 50 to 200 Hz.

11. The inductive magnetoelectric biochemical reaction system according to claim 1 wherein the secondary coil employs a glass spiral tube as a support tube of the conductor of the reaction solution which is connected to two ends of the reactant container to form a communication state, a primary feeding port is arranged on an upper end of the reactant container, a secondary feeding port which is in perpendicular communication with the glass spiral tube is arranged on one side of the reactant container, and a glass jacket which allows circulating liquids with different temperatures to flow through is further arranged on the reaction chamber.

12. A biochemical reaction method, comprising:
providing the inductive magnetoelectric biochemical reaction system as defined in claim 1 and
pouring a reaction solution into the reaction unit, applying an AC excitation signal having a frequency of 50 to 200 Hz, a voltage level of 200 to 400 Vp-p and a power of 80 to 200 VA to the primary coil by using the control unit, and causing the rotatable radial magnetic field to rotate at a frequency of 0.1 to 50 Hz, wherein the rotatable radial magnetic field has a central magnetic flux density of 2000 to 3000 Gs.

13. The biochemical reaction method according to claim 12 , further comprising:
generating a sine wave, a triangular wave, a sawtooth wave, a unidirectional square wave, a bidirectional square wave or a customized function signal having a frequency of 50 to 200 Hz and a voltage level of 10 to 20 Vp-p by using a function signal generator, amplifying the signal by using a power amplifier having a power of 80 to 200 VA and a full-power frequency width of 50 to 200 Hz, causing an output AC signal to have a voltage level of 200 to 400 Vp-p, and exciting the primary coil using the output AC signal.

Assignees

• Univ Jiangnan

Inventors

• Xu Xueming
• Yang Na
• Jin Yamei
• Zhang Nannan
• Li Dandan
• Wu Fengfeng
• Jin Zhengyu
• Chen Yisheng
• Zhou Xing
• Jiao Aiquan
• Ren Jie

Classifications

• C12P19/02

  Monosaccharides (2-ketogulonic acid C12P7/60) · CPC title

• B01J2219/0854

  employing electromagnets · CPC title

• C12P19/04

  Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds · CPC title

• C12P7/58

  Aldonic, ketoaldonic or saccharic acids (uronic acids C12P19/00) · CPC title

• C12P7/62

  Carboxylic acid esters · CPC title