Antibody evolution immunogens
US-2015366961-A1 · Dec 24, 2015 · US
Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity
US9782472B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9782472-B2 |
| Application number | US-201113079472-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 4, 2011 |
| Priority date | Oct 4, 2008 |
| Publication date | Oct 10, 2017 |
| Grant date | Oct 10, 2017 |
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- Title
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Abstract
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Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity.
First claim
Opening claim text (preview).
The invention claimed is: 1. A formulation comprising an HIV envelope glycoprotein polypeptide comprising a single amino acid substitution in a helix of the HIV envelope glycoprotein polypeptide, wherein the helix is selected from the group consisting of the N36 helix and the C34 helix, wherein said single amino acid substitution increases the ability of said polypeptide to bind neutralizing antibodies, wherein the single amino acid substitution is selected from the group consisting of V551[*], Q553[*], and Q655[*], where [*] represents any amino acid other than Q or N, and wherein the numbering of the substituted amino acid is with reference to the amino acid sequence set forth in SEQ ID NO: 16. 2. The formulation of claim 1 , comprising an excipient, carrier or adjuvant. 3. The formulation of claim 1 , wherein the single amino acid substitution is V551[*], where [*] represents any amino acid other than Q or N. 4. The formulation of claim 1 , wherein the single amino acid substitution is Q553[*], where [*] represents any amino acid other than Q or N. 5. The formulation of claim 1 , wherein the single amino acid substitution is Q655[*], where [*] represents any amino acid other than Q or N. 6. The formulation of claim 5 , wherein the single amino acid substitution is Q655R. 7. The formulation of claim 5 , wherein the polypeptide comprises the sequence set forth in SEQ ID NO: 16. 8. The formulation of claim 3 , comprising an excipient, a carrier or an adjuvant. 9. The formulation of claim 4 , comprising an excipient, a carrier or an adjuvant. 10. The formulation of claim 5 , comprising an excipient, a carrier or an adjuvant. 11. The formulation of claim 6 , comprising an excipient, a carrier or an adjuvant. 12. The formulation of claim 7 , comprising an excipient, a carrier or an adjuvant.
Assignees
Inventors
Classifications
New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes · CPC title
env, e.g. gp160, gp110/120, gp41, V3, peptid T, DC4-Binding site · CPC title
from viruses · CPC title
- A61K39/21Primary
Retroviridae, e.g. equine infectious anemia virus · CPC title
from virus · CPC title
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- What does patent US9782472B2 cover?
- Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity.
- Who is the assignee on this patent?
- Berman Phillip, O'Rourke Sara, Scott William, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/21. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 10 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).