Cyclohexyl beta-hydroxy alkyl amines and medical uses thereof
US-2024390298-A1 · Nov 28, 2024 · US
Solid ambroxol-containing preparation
US9782365B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9782365-B2 |
| Application number | US-201214006183-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 15, 2012 |
| Priority date | Mar 21, 2011 |
| Publication date | Oct 10, 2017 |
| Grant date | Oct 10, 2017 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present invention relates to solid preparations containing ambroxol which are obtainable by melt extrusion of the mixture consisting of a) 30 to 80% by weight of ambroxol hydrochloride, b) 2 to 68% by weight of at least one hydrogenated vegetable oil, c) 2 to 68% by weight of at least one mixture containing fatty acid ester and/or hydroxy fatty acid ester and d) 0 to 66% by weight of one or more pharmaceutical adjuvants, based in each case on the total amount of the preparation and its use for secretolytic treatment in acute and chronic bronchopulmonary diseases.
First claim
Opening claim text (preview).
The invention claimed is: 1. A solid formulation containing ambroxol, prepared by the process of melt extrusion of a mixture consisting of a) 70-80% by weight of ambroxol hydrochloride, b) 5-20% by weight of hydrogenated castor oil having a melting point of 70 to 90° C., c) 5-20% by weight of carnauba wax having a melting point of 55 to 90°, and d) 0-5% by weight of one or more pharmaceutical excipients, based in each case on the total amount of the preparation. 2. A method of preparing a solid formulation comprising ambroxol hydrochloride comprising melt extruding a composition consisting of: a) 70-80% by weight of ambroxol hydrochloride, b) 5-20% by weight of hydrogenated castor oil having a melting point of 70 to 90° C., c) 5-20% by weight of carnauba wax having a melting point of 55 to 90° C., and d) 0-5% by weight of one or more pharmaceutical excipients, wherein the amount of each of the components a) to d) is based on the total amount of the solid formulation. 3. A pharmaceutical formulation consisting of a) 70-80% by weight of ambroxol hydrochloride, b) 5-20% by weight of hydrogenated castor oil having a melting point of 70 to 90° C., c) 5-20% by weight of carnauba wax having a melting point of 55 to 90° C., and d) 0-5% by weight of one or more pharmaceutical excipients, based in each case on the total amount of the formulation. 4. The pharmaceutical formulation of claim 3 , wherein the one or more pharmaceutical excipients comprises stearyl alcohol that is present in the formulation. 5. A method of using the formulation according to claim 3 for secretolytic treatment in acute and chronic bronchopulmonary diseases.
Assignees
Inventors
Classifications
resulting in granules or microspheres of the matrix type containing more than 5% of excipient · CPC title
Organic compounds, e.g. phospholipids, fats · CPC title
- A61K31/137Primary
Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone} · CPC title
Mucolytics · CPC title
Expectorants · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9782365B2 cover?
- The present invention relates to solid preparations containing ambroxol which are obtainable by melt extrusion of the mixture consisting of a) 30 to 80% by weight of ambroxol hydrochloride, b) 2 to 68% by weight of at least one hydrogenated vegetable oil, c) 2 to 68% by weight of at least one mixture containing fatty acid ester and/or hydroxy fatty acid ester and d) 0 to 66% by weight of one or…
- Who is the assignee on this patent?
- Brickl Rolf-Stefan, Krenkel Herrad-Odilia, Sanofi Aventis Deutschland
- What technology area does this patent fall under?
- Primary CPC classification A61K31/137. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 10 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).