Anticonvulsant activity of turmeric oil and bisabolene sesquiterpenoids

Patent metadata

Field	Value
Publication number	US-9782361-B2
Application number	US-201214130702-A
Country	US
Kind code	B2
Filing date	Jul 4, 2012
Priority date	Jul 4, 2011
Publication date	Oct 10, 2017
Grant date	Oct 10, 2017

Abstract

The present invention relates to the anti-convulsant activity of turmeric oil and its volatile bisabolene sesquiterpenoids ar- turmerone, α-turmerone, β-turmerone (curlone) and α-atlantone, as an anticonvulsant agent for the treatment of epilepsy and/or as therapeutic agents for the treatment of disorders of the central nervous system, including tremor, pain, mood disorders (including depression, bipolar disorder, attention deficit-hyperactivity disorder, and schizophrenia), and neurodegenerative diseases.

First claim

The invention claimed is:

1. A method for treating convulsive disorders of the central nervous system comprising administering to a subject in need thereof an effective amount of an anticonvulsant therapeutic agent consisting of one or more bisabolene sesquiterpenoids of turmeric essential oil.

2. The method of claim 1 wherein the turmeric essential oil is obtained from a Curcuma genus.

3. The method of claim 1 wherein the one or more bisabolene sesquiterpenoids is selected from the group consisting of Ar-turmerone, α-turmerone, β-turmerone, and α-atlantone, and combinations thereof.

4. The method of claim 1 wherein the anticonvulsant therapeutic agent is in the form of a liquid composition.

5. The method of claim 1 wherein the convulsive disorders of the central nervous system include epileptic seizures, symptoms associated with epileptic seizures, seizure-like behaviors, epilepsy, and tremor.

6. The method of claim 1 wherein the convulsive disorder of the central nervous system is epilepsy.

7. A method for treating convulsive disorders of the central nervous system comprising administering to a subject in need thereof an effective amount of an anticonvulsant therapeutic agent consisting of turmeric essential oil.

8. The method of claim 7 wherein the convulsive disorders of the central nervous system include epileptic seizures, symptoms associated with epileptic seizures, seizure-like behaviors, epilepsy, and tremor.

9. The method of claim 7 wherein the convulsive disorder of the central nervous system is epilepsy.

Assignees

• De Witte Peter A M
• Esguerra Camila V
• Crawford Alexander D
• Orellana Paucar Adriana Monserrath
• Univ Leuven Kath

Inventors

• De Witte Peter A M
• Esguerra Camila V
• Crawford Alexander D
• Orellana Paucar Adriana Monserrath

Classifications

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/24

  Antidepressants · CPC title

• A61P25/08

  Antiepileptics; Anticonvulsants · CPC title

• A61K31/12 Primary

  Ketones · CPC title

• A61K36/9066

  Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger · CPC title