Antibodies targeting talaromyces marneffei mp1p protein and methods of use thereof
US-2024199726-A1 · Jun 20, 2024 · US
US9778266B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9778266-B2 |
| Application number | US-201313890864-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 9, 2013 |
| Priority date | Dec 28, 2005 |
| Publication date | Oct 3, 2017 |
| Grant date | Oct 3, 2017 |
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Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6C, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}. This new serotype may be included in pneumococcal vaccines.
Opening claim text (preview).
The invention claimed is: 1. An assay component comprising an isolated antigen binding molecule that binds specifically to a polysaccharide repeating unit: {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}. 2. An assay component comprising an isolated antigen binding molecule that binds with specificity to an antigen consisting of a polysaccharide repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}. 3. The assay component of claim 1 , wherein the isolated antigen binding molecule is a recombinant antigen binding molecule, a synthetic antigen binding molecule, a monoclonal antibody, or a polyclonal antibody. 4. An assay component that binds specifically to a polysaccharide having the repeating unit: {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}, wherein the component comprises a monoclonal antibody is able to opsonize pneumococcal serotype designate 6C. 5. The assay component of claim 1 or 2 , wherein said antigen binding molecule is bound to an artificial solid surface.
Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof · CPC title
Streptococcus (G) · CPC title
Streptococcus · CPC title
Streptococcus; Staphylococcus · CPC title
Streptococcus · CPC title
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