Fabrication of a fluorescent material for sensing an analyte

Patent metadata

Field	Value
Publication number	US-9778190-B2
Application number	US-201514807033-A
Country	US
Kind code	B2
Filing date	Jul 23, 2015
Priority date	Jul 23, 2014
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.

First claim

What is claimed is:

1. An analyte indicator comprising:
a porous base;
a polymer unit attached or polymerized onto or out of the porous base; and
an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit.

2. The analyte indicator of claim 1 , wherein the analyte indicator retains its physical, chemical, and optical properties in the presence of compression.

3. The analyte indicator of claim 1 , wherein the porous base does not vary in opacity.

4. The analyte indicator of claim 1 , wherein the polymer unit is hydrophilic or amphiphilic.

5. The analyte indicator of claim 1 , wherein the analyte sensing element is one or more indicator molecule.

6. The analyte indicator of claim 1 , wherein the analyte sensing element comprises an indicator polymer chain.

7. The analyte indicator of claim 6 , wherein the indicator polymer chain comprises indicator molecules.

8. The analyte indicator of claim 6 , wherein the analyte sensing element comprises indicator polymer chains, and each of the indicator polymer chains of the analyte sensing element comprises indicator molecules.

9. The analyte indicator of claim 6 , wherein the indicator polymer chain is hydrophilic or amphiphilic.

10. The analyte indicator of claim 1 , wherein the base comprises nylon, cellulose, cellulose acetate, polypropylene, polyethylene, poly(ethylene terephthalate), poly(ether sulfone), poly(vinylidene difluoride), or poly(tetrafluoroethylene).

11. The analyte indicator of claim 1 , wherein the polymer unit is a polyethylene glycol (PEG) unit.

12. The analyte indicator of claim 1 , wherein the porous base is flexible.

13. The analyte indicator of claim 1 , further comprising:
a second polymer unit attached or polymerized onto or out of the porous base; and
a second analyte sensing element attached to the second polymer unit or copolymerized with the second polymer unit.

14. The analyte indicator of claim 5 , wherein the one or more indicator molecule emits light to indicate whether analyte is present.

15. The analyte indicator of claim 5 , wherein the one or more indicator molecule reversibly binds analyte.

16. The analyte indicator of claim 7 , wherein the indicator molecules emit light to indicate whether analyte is present.

17. The analyte indicator of claim 7 , wherein the indicator molecules reversibly bind analyte.

Assignees

• Senseonics Inc

Inventors

• Huffstetler Philip
• Emken Jeremy
• Whitehurst Todd

Classifications

• G01N31/22

  using chemical indicators (G01N31/02 takes precedence) · CPC title

• G01N21/6428 Primary

  Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53) · CPC title

• G01N21/77

  by observing the effect on a chemical indicator · CPC title

• G01N2021/773

  Porous polymer jacket; Polymer matrix with indicator · CPC title

• G01N33/582

  with fluorescent label · CPC title