Asgpr-binding compounds for the degradation of extracellular proteins
US-2024424108-A1 · Dec 26, 2024 · US
US9777246B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9777246-B2 |
| Application number | US-201414765461-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 26, 2014 |
| Priority date | Mar 22, 2013 |
| Publication date | Oct 3, 2017 |
| Grant date | Oct 3, 2017 |
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The current invention is directed towards compounds of the general formula (I), wherein the integers are defined as follows: R 1 is —(CH 2 )nCH(CH 3 ) 2 , R 2 is —(CH 2 ) n+2 CH(CH 3 ) 2 , G 1 selected from monosaccharides with 4 to 6 carbon atoms, x in the range of from 1.1 to 4, n is a number in the range of from zero to 3.
Opening claim text (preview).
The invention claimed is: 1. Mixture of compounds of general formula (I) wherein: R 1 is —(CH 2 ) n CH(CH 3 ) 2 , R 2 is —(CH 2 ) n+2 CH(CH 3 ) 2 , G 1 selected from monosaccharides with 4 to 6 carbon atoms, x in the range of from 1.1 to 4, n is a number in the range of from zero to 3. 2. Mixture of compounds according to claim 1 , characterized in that G 1 is selected from glucose, arabinose and xylose. 3. Mixture of compounds according to claim 1 , characterized in that x is in the range of from 1.15 to 1.9. 4. Mixture of compounds according to claim 1 , characterized in that n is zero. 5. Mixture of compounds according to claim 1 , characterized in that in molecules with x being 2 or more, the saccharide groups are linked in 1,4-position(s). 6. Mixture, containing at least one mixture of compounds according to claim 1 and at least one of its isomers in which the sugar part is identical to G 1 but the alkyl group is different. 7. Mixture, containing at least one mixture of compounds according to claim 1 and at least one non-ionic surfactant, selected from alkoxylated fatty alcohols and hydroxyl-group containing non-ionic surfactants. 8. Process for making a mixture of compounds according to claim 1 , comprising the step of reacting an alcohol of the general formula (II) with a monosaccharide, disaccharide or polysaccharide bearing a G 1 group in the presence of a catalyst. 9. Aqueous formulation containing in the range of from 0.05 to 50% by weight of one mixture of compounds according to claim 1 . 10. An aqueous formulation comprising from 0.05 to 50% by weight of said mixture of compounds of general formula (I) according to claim 1 , and further comprising at least one by-product or starting material, stemming from the synthesis of said mixture of compounds. 11. Process for cleaning hard surfaces or fibers by contacting a hard surface or fiber or an arrangement of fibers with at least one aqueous formulation containing a mixture of compounds according to claim 1 . 12. Process according to claim 11 , characterized in that the cleaning comprises a degreasing.
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