Production method of medical polyoxypropylene polymer and production method of medical polyoxypropylene/polyoxyethylene block copolymer

Patent metadata

Field	Value
Publication number	US-9777113-B2
Application number	US-201415033303-A
Country	US
Kind code	B2
Filing date	Oct 24, 2014
Priority date	Oct 31, 2013
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

A method of producing a medical polyoxypropylene polymer and a polyoxypropylene/polyoxyethylene block copolymer including (A) adding to a polyoxypropylene polymer which is obtained by ring-opening polymerization of propylene oxide to a starting substance having an active hydrogen reacting with the propylene oxide and contains allyl ether as an impurity, a tertiary alkoxide of alkali metal in an excess amount based on a molar number of the active hydrogen of the starting substance and heat treating at 115° C. or less to isomerize the allyl ether to propenyl ether; and (B) adding a mineral acid to the product obtained in step (A) to adjust pH to 4 or less and treating at 70° C. or less to hydrolyze the propenyl ether. Also disclosed is a method of producing a medical polyoxypropylene/polyoxyethylene block copolymer which includes performing ring-opening polymerization of ethylene oxide to the polyoxypropylene polymer obtained above.

First claim

The invention claimed is:

1. A production method of a medical polyoxypropylene polymer, comprising the following steps:
(A) a step of adding to a polyoxypropylene polymer which is obtained by ring-opening polymerization of propylene oxide to a starting substance having an active hydrogen reacting with the propylene oxide and contains allyl ether as an impurity, a tertiary alkoxide of alkali metal in an excess amount based on a molar number of the active hydrogen of the starting substance and heat treating at 115° C. or less to isomerize the allyl ether to propenyl ether; and
(B) a step of adding a mineral acid to the product obtained in the step (A) to adjust pH to 4 or less and treating at 70° C. or less to hydrolyze the propenyl ether.

2. The method as claimed in claim 1 , performing after the step (B) described above, at least one of (C) a step of washing the polyoxypropylene polymer with water and (D) a step of treating the polyoxypropylene polymer with an inorganic adsorbent composed of an oxide containing at least one of aluminum and silicon.

3. A production method of a medical polyoxypropylene/polyoxyethylene block copolymer comprising a step of performing ring-opening polymerization of ethylene oxide to the polyoxypropylene polymer obtained by the method as claimed in claim 1 .

4. A production method of a medical polyoxypropylene/polyoxyethylene block copolymer comprising a step of performing ring-opening polymerization of ethylene oxide to the polyoxypropylene polymer obtained by the method as claimed in claim 2 .

Assignees

• Nof Corp

Inventors

• TSUBUSAKI Takuma
• Yamamoto Yuji

Classifications

• C08G65/2606

  containing hydroxyl groups · CPC title

• C08G65/2696

  characterised by the process or apparatus used · CPC title

• C08G65/331

  containing oxygen {(cyclic ether compounds C08G65/26)} · CPC title

• C08G65/30

  Post-polymerisation treatment, e.g. recovery, purification, drying · CPC title

• C08L71/00

  Compositions of polyethers obtained by reactions forming an ether link in the main chain (of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06); Compositions of derivatives of such polymers · CPC title