Liquid mixing method and device

Patent metadata

Field	Value
Publication number	US-9776145-B2
Application number	US-201214125417-A
Country	US
Kind code	B2
Filing date	Jun 7, 2012
Priority date	Jun 22, 2011
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

Provided is a method of mixing first and second liquids having mutual solubility inside a mixing flow channel formed by a micro flow channel. This method includes: causing the first and second liquids to be joined to each other inside the mixing flow channel; and forming a slug flow, in which mixing subject cells ( 60 ) formed by the joined liquid and insoluble fluid cells ( 63 ) formed by an insoluble fluid are alternately arranged, inside a flow channel at the downstream side of an insoluble fluid supply position in a manner such that the insoluble fluid having insolubility with respect to both mixing subject liquids is supplied to the joined liquid flowing through the flow channel in a direction intersecting the flow channel so that the joined liquid is divided with a gap therebetween, thereby mixing the first mixing subject liquid and the second mixing subject liquid contained in each mixing subject cell inside the downstream flow channel.

First claim

The invention claimed is:

1. A liquid mixing method of mixing first and second liquids having mutual solubility in a device comprising:
a flow channel forming body which forms a mixing flow channel for mixing the first and second liquids with each other;
a first liquid supply unit which supplies the first liquid to the flow channel forming body;
a second liquid supply unit which supplies the second liquid to the flow channel forming body; and
an insoluble fluid supply unit which supplies an insoluble fluid having insolubility with respect to both first and second liquids to the flow channel forming body,
wherein the mixing flow channel formed by the flow channel forming body comprises
a first liquid introduction unit into which the first liquid supplied from the first liquid supply unit is introduced,
a second liquid introduction unit into which the second liquid supplied from the second liquid supply unit is introduced and which comprises a terminal end communicating with a terminal end of the first liquid introduction unit so that the introduced second liquid is joined to the first liquid introduced to the first liquid introduction unit,
a mixing unit which is connected to the terminal ends of both liquid introduction units and mixes the liquids joined to each other at the terminal ends in a flowing state, and
an insoluble fluid introduction unit which comprises a terminal end communicating with the mixing unit so as to form a slug flow, in which mixing subject cells formed by the joined liquid and insoluble fluid cells formed by an insoluble fluid are alternately arranged, inside the mixing unit at a downstream side of an insoluble fluid introduction position in a manner such that the insoluble fluid supplied from the insoluble fluid supply unit is introduced to the joined liquid flowing through the mixing unit at a middle position of the mixing unit in a direction intersecting the mixing unit,

wherein the flow channel forming body comprises a base body which is provided with a groove forming the mixing flow channel and a lid body which is mounted on the base body so as to cover the groove, and
wherein the base body is formed by a substrate having a first side surface and a second side surface opposite thereof, and
wherein the substrate is configured with:
a first liquid groove which is formed in the first side surface and forming the first liquid introduction unit,
a mixing groove which is formed in the first side surface so as to be connected to a terminal end of the first liquid groove and forming the mixing unit,
a second liquid groove which is formed in the second side surface and forming the second liquid introduction unit and has a shape in which a terminal end of the groove is located at a rear side of the terminal end of the first liquid groove,
an insoluble fluid groove which is formed in the second side surface and forming the insoluble fluid introduction unit and has a shape in which a terminal end of the groove is located at a rear side of a middle position of the mixing unit,
a joining hole which penetrates the substrate in a thickness direction so that the terminal end of the first liquid groove communicates with the terminal end of the second liquid groove and causes the first liquid and the second liquid to be joined to each other, and
an insoluble fluid introduction hole which penetrates the substrate in the thickness direction so that a middle portion of the mixing groove communicates with the terminal end of the insoluble fluid groove and enables the introduction of the insoluble fluid with respect to the liquid flowing through the mixing groove,
the method comprising:
joining the first and second liquids to each other inside the mixing unit to obtain a joined liquid; and
forming a slug flow, in which mixing cells formed by the joined liquid and insoluble fluid cells formed by an insoluble fluid are alternately arranged, inside the mixing groove in a manner such that the insoluble fluid having insolubility with respect to both the first and second liquids is supplied to the joined liquid flowing through the mixing move so that the joined liquid is divided with a gap therebetween, thereby mixing the first liquid and the second liquid contained in each mixing cell,
wherein an introduction flow rate of the insoluble fluid is set so that a volume ratio between the mixing cell and the insoluble fluid cell in the slug flow is equal to or larger than ½ and equal to or smaller than 2.

2. The method according to claim 1 ,
wherein the insoluble fluid is a gas.

3. The method according to claim 2 , further comprising:
separating the insoluble fluid from the first and second liquids after the first and second liquids are completely mixed with each other.

Assignees

• Nishikawa Daisuke
• Yamashita Takeshi
• Nishimura Makoto
• Noishiki Koji
• Kobe Steel Ltd

Inventors

• Nishikawa Daisuke
• Yamashita Takeshi
• Nishimura Makoto
• Noishiki Koji

Classifications

• B01F13/0071

  Operations & Transport · mapped topic

• B01F3/0876 Primary

  Operations & Transport · mapped topic

• B01J2219/00889

  Mixing · CPC title

• B01J19/0093

  Microreactors, e.g. miniaturised or microfabricated reactors (laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027) · CPC title

• B81B1/00

  Devices without movable or flexible elements, e.g. microcapillary devices · CPC title