Biocompatible surfaces and devices incorporating such surfaces

Patent metadata

Field	Value
Publication number	US-9775933-B2
Application number	US-201313773937-A
Country	US
Kind code	B2
Filing date	Feb 22, 2013
Priority date	Mar 2, 2012
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.

First claim

What is claimed is:

1. A blood contact surface comprising
a polytetrafluoroethylene microstructure of nodes and fibrils in both an x direction and in a substantially perpendicular y direction;
wherein the nodes and fibrils have a mean distance between adjacent nodes of 5 micron or less; and
wherein the mean width of the 32 largest nodes in a representative 10,000× SEM micrograph is less than about 1.5 micron.

2. The blood contact surface of claim 1 wherein the nodes and fibrils have a ratio of mean distances between adjacent nodes in the x and y directions of about 2:1 to 1.1.

3. The blood contact surface of claim 2 wherein the ratio of mean distances between adjacent nodes in the x and y directions is about 1:1.

4. The blood contact surface of claim 1 wherein the expanded polytetrafluoroethylene comprises a multi-axially expanded polytetrafluoroethylene.

5. The blood contact surface of claim 4 wherein the expanded polytetrafluoroethylene comprises a bi-axially expanded polytetrafluoroethylene.

6. The blood contact surface of claim 1 wherein the expanded polytetrafluoroethylene comprises fibrils extended outwardly from the nodes in substantially perpendicular directions.

7. The blood contact surface of claim 1 wherein the mean width of the nodes comprises less than about 1.25 micron.

8. The blood contact surface of claim 1 wherein the mean width of the nodes is less than about 1 micron.

9. The blood contact surface of claim 1 wherein the ratio of mean distances between adjacent nodes in the x and y directions is less than 1.5 to 1.

10. The blood contact surface of claim 1 wherein the microstructure substantially prevents cellular in-growth.

11. The blood contact surface of claim 1 wherein the blood contact surface is incorporated in an implantable medical device.

12. The blood contact surface of claim 1 wherein the blood contact surface is incorporated in a non-implantable medical device.

13. The blood contact surface of claim 1 wherein the mean distance between adjacent nodes is less than about 4 micron.

14. The blood contact surface of claim 13 wherein the mean distance between adjacent nodes is less than about 3 micron.

15. The blood contact surface of claim 11 wherein the implantable medical device includes a stent.

16. The blood contact surface of claim 1 wherein endothelial cells attach intimately to the node and fibril microstructure.

Assignees

• Gore & Ass

Inventors

• Knisley Keith A
• Marla Vishnu T
• Radspinner Rachel
• Silvagni Paul A
• Strid Jason J
• Vonesh Michael J

Classifications

• A61L33/064

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L33/062 takes precedence) · CPC title

• A61F2/0077

  Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence) · CPC title

• A61L33/007

  Porous materials, e.g. foams or sponges · CPC title

• A61L2300/416

  Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus · CPC title

• A61L31/10

  Macromolecular materials · CPC title