Solution blow spun polymer fibers, polymer blends therefor and methods and use thereof

Patent metadata

Field	Value
Publication number	US-9775929-B2
Application number	US-201514685175-A
Country	US
Kind code	B2
Filing date	Apr 13, 2015
Priority date	Apr 14, 2014
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

Compositions comprising biomedical polymers, and in particular unique blends of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) are provided. Methods of forming polymer fibers using such compositions and solution blow spinning techniques are also provided, as well as methods of delivering the blow spun polymer fibers onto a surface (e.g., such as tissue for use as a surgical scaffold, sealant or tissue adhesive).

First claim

What is claimed is:

1. A biocompatible composition comprising:
(A) a first solution of between about 1% and about 20% weight per volume (w/v) poly(lactic-co-glycolic acid) (PLGA) having a weight average molecular weight of between about 50 kDa and about 200 kDa;
(B) a second solution of between about 1% and about 20% w/v PLGA having a weight average molecular weight of between about 5 kDa and about 15 kDa; and
(C) a third solution of between about 1% and about 20% w/v poly(ethylene glycol) (PEG).

2. The composition of claim 1 , wherein said first solution or said second solution comprises between about 3% and about 15% w/v PLGA.

3. The composition of claim 1 , wherein said third solution comprises between about 1% and about 10% w/v PEG.

4. The composition of claim 1 , wherein each of said first solution and said second solution comprises between about 3% and about 10% w/v PLGA and said third solution comprises between about 1% and about 5% w/v PEG.

5. The composition of claim 1 , wherein said solution of said PEG has a weight average molecular weight of between about 1 kDa and about 10 kDa.

6. The composition of claim 1 , further comprising a volatile solvent.

7. The composition of claim 6 , wherein said volatile solvent is acetone or ethyl acetate.

8. The composition of 1 , wherein at least one of said PLGA or said PEG is modified to contain a therapeutic agent.

9. The composition of claim 8 , wherein said therapeutic agent is selected from the group consisting of a protein, a peptide, an amine, an aliphatic compound, and an antibiotic.

10. A biocompatible polymer fiber construct comprising blow spun polymer fibers formed from a composition comprising:
(A) a first solution of between about 1% and about 20% weight per volume (w/v) poly(lactic-co-glycolic acid) (PLGA) having a weight average molecular weight of between about 50 kDa and about 200 kDa;
(B) a second solution of between about 1% and about 20% w/v PLGA having a weight average molecular weight of between about 5 kDa and about 15 kDa; and
(C) a third solution of between about 1% and about 20% w/v poly(ethylene glycol) (PEG).

11. The construct of claim 10 , wherein said first solution or said second solution comprises between about 3% and about 15% w/v PLGA.

12. The construct of claim 10 , wherein said third solution comprises between about 1% and about 10% w/v PEG.

13. The construct of claim 10 , wherein each of said first solution and said second solution comprises between about 3% and about 10% w/v PLGA and said third solution comprises between about 1% and about 5% w/v PEG.

14. The construct of claim 10 , which is a tissue sealant, adhesive, hemostatic or scaffolding material.

15. The construct of claim 10 , wherein said polymer fibers have an average diameter of less than about 500 nanometers.

16. A method of forming a polymer fiber construct, comprising:
forming a plurality of polymer fibers using a solution blow spinning process, wherein said polymer fibers are formed from a composition comprising: i) a first solution of between about 1% and about 20% weight per volume (w/v) poly(lactic-co-glycolic acid) (PLGA) having a weight average molecular weight of between about 50 kDa and about 200 kDa; ii) a second solution of between about 1% and about 20% w/v PLGA having a weight average molecular weight of between about 5 kDa and about 15 kDa; and iii) a third solution of between about 1% and about 20% w/v poly(ethylene glycol) (PEG); and
depositing said plurality of blow spun polymer fibers onto a target to form a conformal polymer fiber construct thereon.

17. The method of claim 16 , wherein said target is a tissue surface, said polymer fiber construct formed on said tissue surface in vivo.

18. The method of claim 16 , wherein said first solution or said second solution comprises between about 3% and about 15% w/v PLGA.

19. The method of claim 16 , wherein said third solution comprises between about 1% and about 10% w/v PEG.

20. The method of claim 16 , wherein each of said first solution and said second solution comprises between about 3% and about 10% w/v PLGA and said third solution comprises between about 1% and about 5% w/v PEG.

21. A biocompatible polymer fiber construct comprising blow spun polymer fibers formed from a solution comprising:
(A) between about 1% and about 20% weight per volume (w/v) poly(lactic-co-glycolic acid) (PLGA) having a weight average molecular weight of between about 50 kDa and about 200 kDa;
(B) between about 1% and about 20% w/v PLGA having a weight average molecular weight of between about 5 kDa and about 15 kDa; and
(C) between about 1% and about 20% w/v poly(ethylene glycol) (PEG).

22. The construct of claim 21 , wherein said solution comprises between about 3% and about 10% w/v PLGA having a weight average molecular weight of between about 50kDa and about 200 kDa, and between about 3% and about 10% w/v PLGA having a weight average molecular weight of between about 5 kDa and about 15 kDa.

23. The construct of claim 22 , wherein said solution comprises between about 1% and about 5% w/v PEG.

24. The construct of claim 21 , which is a tissue sealant, adhesive, hemostatic or scaffolding material.

25. A method of forming a polymer fiber construct, comprising:
forming a plurality of polymer fibers using a solution blow spinning process, wherein said polymer fibers are formed from a solution comprising: i) between about 1% and about 20% weight per volume (w/v) poly(lactic-co-glycolic acid) (PLGA) having a weight average molecular weight of between about 50 kDa and about 200 kDa; ii) between about 1% and about 20% w/v PLGA having a weight average molecular weight of between about 5 kDa and about 15 kDa; and iii) between about 1% and about 20% w/v poly(ethylene glycol) (PEG); and
depositing said plurality of blow spun polymer fibers onto a target to form a conformal polymer fiber construct thereon.

26. The method of claim 25 , wherein said target is a tissue surface, said polymer fiber construct formed on said tissue surface in vivo.

27. The method of claim 25 , wherein said solution comprises between about 3% and about 10% w/v PLGA having a weight average molecular weight of between about 50kDa and about 200 kDa, and between about 3% and about 10% w/v PLGA having a weight average molecular weight of between about 5 kDa and about 15 kDa.

28. The method of claim 27 , wherein said solution comprises between about 1% and about 5% w/v PEG.

Assignees

• Univ Maryland
• Children'S Nat Medical Center
• Univ Maryland

Inventors

• Behrens Adam
• Kofinas Peter
• Sikorski Michael
• Sandler Anthony
• Srinivasan Priya
• Lee Nora

Classifications

• A61L24/0015

  Medicaments; Biocides · CPC title

• A61L24/043 Primary

  Mixtures of macromolecular materials · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61L27/26

  Mixtures of macromolecular compounds · CPC title

• C08L71/02

  Polyalkylene oxides · CPC title