Curcumin coated magnetite nanoparticles for biomedical applications

Patent metadata

Field	Value
Publication number	US-9775919-B2
Application number	US-201615202716-A
Country	US
Kind code	B2
Filing date	Jul 6, 2016
Priority date	Jan 17, 2012
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

The present invention discloses biocompatible, stable curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles (USPION) for biomedical applications. Disclosed herein is also a simple one-pot process for the synthesis of biocompatible, stable curcumin or its derivatives coated ultra-small superparamagnetic iron oxide nanoparticles in absence of a linker or binder. The curcumin or its derivatives coated ultra-small super paramagnetic iron oxide nanoparticles of the present invention retains the medicinal, radical scavenging and fluorescence properties of curcumin.

First claim

The invention claimed is:

1. A one-pot process for the synthesis of curcumin coated magnetite nanoparticles, which are biocompatible, stable curcumin coated ultra-small super paramagnetic iron oxide nanoparticles devoid of a linker or binder, the process comprising:
(a) dissolving aqueous mixture of FeCl 3 .6H 2 O and FeCl 2 .4H 2 O in the molar ratio ranging between 1.5:1 to 2:1 in a base under inert atmosphere and stirring until complete formation and growth of magnetite nanoparticles;
(b) adding dilute mineral acid to the solution as obtained in step (a) until the solution has a pH of about 9;
(c) adding drop wise curcumin solution dissolved in a base to the solution of step (b) under inert atmosphere, maintaining the pH at about 9 followed by stirring the dispersion at a temperature in the range of 50-100° C. followed by cooling; and
(d) dialysing the dispersion of step (c) against water to remove excess curcumin and drying in a vacuum to obtain the product.

2. The process according to claim 1 , wherein the base used is an alkali hydroxide.

3. The process according to claim 2 , wherein the alkali hydroxide is ammonium hydroxide.

4. The process according to claim 1 , wherein the mineral acid used is nitric acid.

5. The process according to claim 1 , wherein the curcumin coated magnetite nanoparticles have a particle size of about 3 nm.

Assignees

• Council Scient Ind Res

Inventors

• Pattayil Alias Joy
• Jayaprabha Kunnoth Naduvilidam

Classifications

• A61K9/0009 Primary

  involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis · CPC title

• A61K49/1833 Primary

  having a (super)(para)magnetic core coated or functionalised with a small organic molecule (oligomeric, polymeric, dendrimeric A61K49/1851) · CPC title

• A61K9/1682

  Processes · CPC title

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title