Lignans isolated from Lasia spinosa (L.) Thwait

Patent metadata

Field	Value
Publication number	US-9775857-B2
Application number	US-201615190587-A
Country	US
Kind code	B2
Filing date	Jun 23, 2016
Priority date	Jun 23, 2015
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

The present invention relates to chemical constituents of the hydro-alcoholic extract of root of Lasia spinosa (L.) Thwait. More particularly, it relates to the bioactive chemical composition of Lasia spinosa (L.) Thwait and its anticancer effect. The present invention has application in the treatment of human esophageal carcinoma.

First claim

We claim:

1. A method for inhibiting the growth of an esophageal carcinoma in a subject in need thereof by administering to said subject an effective amount of at least one compound selected from lyoniresinol (1), 5,5′-dimethoxysecoiso-lariciresinol (2), 2-(4-hydroxy-3,5-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)-1,2-butanediol (3), (7′S,8S,8R)-4,4′-dihydroxy-3,3′5,5′-tetramethoxy-7′,9-eproxylignan-9′-ol-7-one (4), 5,5′-dimethoxysecoiso-lariciresinol (5), 5′-methyoxlariciresinol (7), dihydrodehydrodiconifery alcohol (8) and syringaresinol (9), or a mixture thereof.

2. The method according to claim 1 wherein the compound is administered in an effective amount via intraperitoneal injection.

3. The method according to claim 2 wherein the effective amount is no more than 2.43 mg/kg per day.

4. The method according to claim 1 wherein the subject in need thereof is a human.

5. A method for inhibiting the growth of an esophageal carcinoma in a subject in need thereof by administering to said subject an effective amount of Lasia spinosa (L.) Thwait root or an extract from Lasia spinosa (L.) Thwait root.

6. The method according to claim 5 wherein the extract is administered via intraperitoneal injection.

7. The method according to claim 5 wherein the subject in need thereof is a human.

Assignees

• Univ Hong Kong Baptist Univ

Inventors

• Bian Zhaoxiang
• Mu Huaixue
• Lin Chengyuan
• Xu Hongxi
• Yang Dajian
• Chen Shilin
• Lu Aiping
• Chan Albert Sun Chi

Classifications

• A61K36/888 Primary

  Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61K31/34

  having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide · CPC title

• A61K31/353

  3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title

• A61K9/0053

  Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title