Osteoconductive and osteoinductive implant for augmentation, stabilization, or defect reconstruction

Patent metadata

Field	Value
Publication number	US-9775712-B2
Application number	US-201514755587-A
Country	US
Kind code	B2
Filing date	Jun 30, 2015
Priority date	Jun 30, 2015
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

Aspects of the present invention provide implants for augmentation, stabilization, or defect reconstruction of bone tissue, comprising a scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following: one or more polylactic acid isomer; one or more polyglycolic acid isomer; and/or allogenic bone material, or similar compound.

First claim

The invention claimed is:

1. A bioresorbable implant for augmentation, stabilization, or defect reconstruction of bone tissue, the implant comprising:
a coextensively bioresorbable scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following:
one or more polylactic acid isomer, and/or
one or more polyglycolic acid isomer; and/or
and optionally additionally comprising allogenic bone material;
the scaffold having a same composition throughout;
whereby the scaffold portion of the implant is coextensively bioresorbable and in situ promotes its complete resorption and replacement by bone via osteoinduction and/or osteoconduction;
wherein the implant further comprises one or more bioresorbable screws that secure the implant at an implantation site; and
wherein the implant is configured for application to a bone of the craniofacial skeleton and is designed for a customized fit in a subject in which the implant is to be applied.

2. The implant of claim 1 , wherein the allogenic bone material comprises demineralized bone matrix.

3. The implant of claim 1 , wherein the scaffold portion is in the form of a mesh structure.

4. The implant of claim 1 , wherein the scaffold portion is in the form of a lattice structure.

5. The implant of claim 1 , further comprising an autologous bone graft embedded within the scaffold portion.

6. The implant of claim 1 , further comprising bone morphogenic protein embedded within the scaffold portion.

7. The implant of claim 1 , wherein the implant is in the form of a sheet.

8. A method for augmentation, stabilization, or defect reconstruction of bone tissue, comprising:
obtaining an implant according to claim 1 ; and
applying the implant to a site of the craniofacial skeleton in need of augmentation, stabilization, or defect reconstruction.

9. The method of claim 8 , wherein the allogenic bone material comprises demineralized bone matrix.

10. The method of claim 8 , wherein the scaffold portion is in the form of a mesh structure.

11. The method of claim 8 , wherein the scaffold portion is in the form of a lattice structure.

12. The method of claim 8 , further comprising embedding an autologous bone graft within the scaffold portion.

13. The method of claim 8 , further comprising embedding bone morphogenic protein within the scaffold portion.

14. The method of claim 8 , wherein the implant is one that is obtained via 3-D printing.

15. The method of claim 8 , wherein applying the implant comprises securing the implant to the site with bioresorbable screws.

16. The method of claim 8 , wherein the implant is in the form of a sheet.

17. The method of claim 8 , wherein the bone is a chin, cheek, or zygoma.

18. The implant of claim 1 , wherein the implant is one that is obtained via 3-D printing.

19. A method for augmentation, stabilization, or defect reconstruction of bone tissue, comprising:
obtaining a bioresorbable implant via 3-D printing, the implant comprising:
a coextensively bioresorbable scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following:
one or more polylactic acid isomer;
one or more polyglycolic acid isomer; and/or
allogenic bone material;
the scaffold having a same composition throughout, whereby the scaffold portion is coextensively bioresorbable and in situ promotes its complete resorption and replacement by bone via osteoinduction and/or osteoconduction; and
applying the implant to a site in need of augmentation, stabilization, or defect reconstruction of bone tissue.

20. The method of claim 19 , wherein the allogenic bone material comprises demineralized bone matrix.

21. The method of claim 19 , wherein the scaffold portion is in the form of a mesh structure.

22. The method of claim 19 , wherein the scaffold portion is in the foi in of a lattice structure.

23. The method of claim 19 , further comprising embedding an autologous bone graft within the scaffold portion.

24. The method of claim 19 , further comprising embedding bone morphogenic protein within the scaffold portion.

25. The method of claim 19 , further comprising, prior to obtaining the implant, designing the implant for a customized fit in a subject in which the implant is to be applied.

26. The method of claim 19 , wherein applying the implant comprises securing the implant to the site with bioresorbable screws.

27. The method of claim 19 , wherein the implant is in the form of a sheet.

28. The method of claim 19 , wherein the implant is applied to a long bone or to a bone of the craniofacial skeleton.

29. The method of claim 28 , wherein the bone is a chin, cheek, or zygoma.

30. A method for obtaining an implant for augmentation, stabilization, or defect reconstruction of bone tissue, comprising:
designing a bioresorbable implant for a customized fit in a subject in which the implant is to be applied;
obtaining the bioresorbable implant, the bioresorbable implant comprising:
a coextensively bioresorbable scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following:
one or more polylactic acid isomer, and/or
one or more polyglycolic acid isomer;
and optionally additionally comprising allogenic bone material;
the scaffold having a same composition throughout, whereby the scaffold portion is coextensively bioresorbable and in situ promotes its complete resorption and replacement by bone via osteoinduction and/or osteoconduction.

31. The method of claim 30 , wherein the allogenic bone material comprises demineralized bone matrix.

32. The method of claim 30 , wherein the scaffold portion is in the form of a mesh structure.

33. The method of claim 30 , wherein the scaffold portion is in the form of a lattice structure.

34. The method of claim 30 , further comprising embedding an autologous bone graft within the scaffold portion.

35. The method of claim 30 , further comprising embedding bone morphogenic protein within the scaffold portion.

36. The method of claim 30 , wherein the implant is one that is obtained via 3-D printing.

37. The method of claim 30 , wherein applying the implant comprises securing the implant to the site with bioresorbable screws.

38. The method of claim 30 , wherein the implant is in the form of a sheet.

39. The method of claim 30 , wherein the implant is applied to a long bone or to a bone of the craniofacial skeleton.

40. The method of claim 39 , wherein the bone is a chin, cheek, or zygoma.

Assignees

• Ching Jessica Allen
• Ford Jonathan Michael
• Decker Summer Joy
• Univ South Florida

Inventors

• Ching Jessica Allen
• Ford Jonathan Michael
• Decker Summer Joy

Classifications

• A61F2230/00

  Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof · CPC title

• A61F2/28 Primary

  Bones · CPC title

• A61L27/00

  Materials for {grafts or} prostheses or for coating {grafts or} prostheses (dental prostheses A61C13/00; shape or structure of prostheses A61F2/00; use of preparations for artificial teeth A61K6/80; artificial kidneys A61M1/14) · CPC title

• A61L27/46

  with phosphorus-containing inorganic fillers · CPC title

• A61L27/3608

  Bone, e.g. demineralised bone matrix [DBM], bone powder · CPC title