Analyte sensors having a membrane with low temperature sensitivity

Patent metadata

Field	Value
Publication number	US-9775544-B2
Application number	US-201615347607-A
Country	US
Kind code	B2
Filing date	Nov 9, 2016
Priority date	May 20, 2011
Publication date	Oct 3, 2017
Grant date	Oct 3, 2017

Abstract

Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

First claim

That which is claimed is:

1. A system comprising:
an analyte sensor comprising:
a counter electrode;
a working electrode comprising a sensing layer thereon, the sensing layer comprising an analyte responsive enzyme; and
a diffusion limiting polymeric membrane disposed on the sensing layer, wherein the polymeric membrane comprises a poly(4-vinylpyridine)-co-polystyrene polymer, an ethylene oxide substituent and a propylene oxide substituent,
wherein diffusion of an analyte through the diffusion limiting membrane to the sensing layer does not change more than 5% per ° C. over a range of physiological temperatures; and

an electrochemical sensor control unit comprising:
a housing; and
a transmitter for transmitting sensor signals from the electrochemical sensor.

2. The system of claim 1 , wherein the sensor control unit further comprises a data storage unit for storing data from the electrochemical sensor.

3. The system of claim 1 , wherein the sensor control unit further comprises a reference voltage generator.

4. The system of claim 1 , wherein the sensing layer comprises a glucose-responsive enzyme.

5. The system of claim 4 , wherein the glucose-responsive enzyme comprises glucose oxidase.

6. The system of claim 1 , wherein the sensing layer further comprises a redox mediator.

7. The system of claim 6 , wherein the redox mediator comprises a ruthenium-containing complex or an osmium-containing complex.

8. The system of claim 6 , wherein one or more of the redox mediator and the enzyme is covalently bound to a polymer.

9. The system of claim 8 , wherein the analyte sensor is an in vivo glucose sensor.

10. The system of claim 8 , wherein the poly(4-vinylpyridine)-co-polystyrene polymer comprises a compound of the formula:

wherein x and y are each positive integers and the ratio of x to y is 1:1.

11. The system of claim 1 , wherein the ethylene oxide substituent and a propylene oxide substituent comprises a formula:

wherein
m, n and o are each independently positive integers,
R′ and R″ are each a linking group, and
EO is ethylene oxide and PO is propylene oxide.

12. The system of claim 1 , wherein the polymeric membrane comprises a compound of the formula:

wherein
x and y are each positive integers,
m, n and o are each independently positive integers,
R′ and R″ are each a linking group, and
EO is ethylene oxide and PO is propylene oxide.

Assignees

• Abbott Diabetes Care Inc

Inventors

• Ouyang Tianmei
• Liu Zenghe
• Goti Yohannes
• Feldman Benjamin J
• Hoss Udo

Classifications

• A61L31/047

  Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046 · CPC title

• A61B5/1468

  using chemical or electrochemical methods, e.g. by polarographic means · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61M2205/3592

  using telemetric means, e.g. radio or optical transmission · CPC title

• A61M2205/3569

  sublocal, e.g. between console and disposable · CPC title