Robotic Microtool Control in an Intelligent Automated In Vitro Fertilization and Intracytoplasmic Sperm Injection Platform
US-2024426856-A1 · Dec 26, 2024 · US
US9772264B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9772264-B2 |
| Application number | US-201214241148-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 17, 2012 |
| Priority date | Sep 22, 2011 |
| Publication date | Sep 26, 2017 |
| Grant date | Sep 26, 2017 |
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An automatic analyzer is capable of controlling the gap between the tip of the sample nozzle and the bottom surface of the reaction container and restricting the sample attached to the tip of the sample nozzle. A movement distance of an arm is calculated and stored while the tip of the sample nozzle contacts a coordinate measurement stand until a stop position detector detects a stop position detection plate. The sample nozzle is moved toward the bottom surface of the reaction container and is stopped at the time when the stop position detector detects the stop position detection plate. The arm is moved upwardly for the movement distance stored in memory from this position. The sample nozzle can be stopped such that the tip of the sample nozzle is contacted to the bottom surface of the reaction container and the bend (warp) of the sample nozzle is restricted.
Opening claim text (preview).
The invention claimed is: 1. An automatic analyzer comprising: a sample dispensing mechanism which moves up and down and rotates, the sample dispensing mechanism including a sample nozzle to dispense a sample into a reaction container and a supporting arm with an elastic member that elastically supports the sample nozzle; a controller configured to control up and down movements and a rotation movement of the supporting arm to move the sample nozzle; a photometer to measure a solution in the reaction container; a capacitance detector set on the dispensing mechanism, the capacitance detector detecting a change of a capacitance of the sample nozzle; a detection plate formed on the sample nozzle; and a stop position detector set on the supporting arm, the stop position detector detecting the detection plate, wherein the controller is further configured to calculate a contact movement distance based on a first position of the supporting arm upon determination that the capacitance detector detects that a capacitance of the sample nozzle changes more than or equal to a constant value and a second position of the supporting arm upon determination that the stop position detector detects the detection plate, wherein the controller is further configured to move the sample nozzle downwardly toward the reaction container, stop a downward movement of the sample nozzle upon determination that the stop position detector detects the detection plate, move the supporting arm upwardly for the contact movement distance, and thereafter dispense the sample from the sample nozzle into the reaction container, and wherein the controller is further configured to control the photometer to measure a solution including the sample in the reaction container. 2. The automatic analyzer according to claim 1 , further comprising: a coordinate measurement stand comprising a substrate and an electrically conductive surface; and a memory, wherein the controller is further configured to move the sample nozzle downwardly toward the coordinate measurement stand, calculate a difference between the first position of the supporting arm when the capacitance detector detects that the capacitance of the sample nozzle changes more than or equal to the constant value from contacting the coordinate measurement stand and the second position of the supporting arm when the stop position detector detects the detection plate, and store the difference as the contact movement distance in the memory. 3. The automatic analyzer according to claim 1 , wherein the controller is further configured to control a first moving speed of the sample nozzle after the sample nozzle dispenses the sample into the reaction container where the first moving speed of the sample nozzle is controlled over a liquid surface separation distance which is a distance from the contact position of the tip of the sample nozzle and the bottom of the reaction container to a separation position of the sample nozzle and a liquid surface of the sample, the controller is further configured to control a second moving speed of the sample nozzle after the sample nozzle separates from the liquid surface, and wherein the first moving speed of the sample nozzle is lower than the second moving speed of the sample nozzle. 4. The automatic analyzer according to claim 3 , wherein the controller is further configured to determine the liquid surface separation distance when the capacitance detector detects that the sample nozzle separates from the liquid surface at the separation position. 5. The automatic analyzer according to claim 3 , wherein the controller is further configured to calculate the liquid surface separation distance based on a dispensed amount of the sample from the sample nozzle into the reaction container. 6. The automatic analyzer according to claim 1 , wherein the controller is further configured to move the sample nozzle downwardly toward the reaction container in which liquid is received, calculate a difference between the first position of the supporting arm when the capacitance detector detects that the capacitance of the sample nozzle changes more than or equal to the constant value and the second position of the supporting arm when the stop position detector detects the detection plate, calculate a height of a liquid in the reaction container, and calculate a value obtained by subtracting the height of the liquid from the difference as the contact movement distance. 7. The automatic analyzer according to claim 1 , wherein the controller is further configured to calculate the contact movement distance based on the first position of the supporting arm causing the sample nozzle to contact a liquid surface of a liquid in the reaction container when the capacitance detector detects that the capacitance of the sample nozzle changes more than or equal to the constant value, the second position of the supporting arm when the stop position detector detects the detection plate, and a height of the liquid in the reaction container.
Fluid level sensing · CPC title
Volumetric liquid transfer · CPC title
Control of the position or alignment of the transfer device · CPC title
Preparing specimens for investigation {including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q}(mounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 {; laboratory gas handling apparatus B01L5/00}) · CPC title
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