Method for producing free powder particles of polyamide impregnated with at least one cosmetic or pharmaceutical agent, and free powder particles of polyamide having a content of at least 25 WT % of a cosmetic or pharmaceutical agent other than water

Patent metadata

Field	Value
Publication number	US-9764167-B2
Application number	US-201013265420-A
Country	US
Kind code	B2
Filing date	Apr 16, 2010
Priority date	Apr 21, 2009
Publication date	Sep 19, 2017
Grant date	Sep 19, 2017

Abstract

The invention relates to a method for producing free powder particles of polyamide, impregnated with at least one cosmetic or pharmaceutical agent. The present invention also relates to free powder particles of polyamide having a content of at least 25% by weight of a cosmetic or pharmaceutical agent other than water, to the use of said particles in a cosmetic, pharmaceutical or perfumery products, and to compositions containing such particles.

First claim

The invention claimed is:

1. A particle consisting of free polyamide-based powder, and at least one cosmetic or pharmaceutical agent other than water, in a solubilizer, said particle being porous, with an SSA of greater than 8 m 2 /g and a content of at least 40% by weight of said at least one cosmetic or pharmaceutical agent other than water, wherein the cosmetic or pharmaceutical agent is in the form of a pure liquid or as a solid dissolved in a solubilizer containing no solvent harmful to the skin, said solubilizer consisting of purified water, thermal water, glycerol, propylene glycol, a glyceride or an essential oil, said polyamide-based particle having a content, as molar percentage, of polyamide 12 of at least 50%, said cosmetic or pharmaceutical agent consisting of lactic acid, a ceramide or a mixture thereof.

2. The particle as claimed in claim 1 , in which said particle has a mean diameter by volume within the range from 3 to 12 μm.

3. The particle as claimed in claim 1 , in which said polyamide-based particle is particles of polyamide, copolyamide, copolyesteramide or their mixtures.

4. The particle as claimed in claim 1 , in which said particle of polyamide-based powder is obtained at least in part by anionic polymerization, by seeding with an inorganic or organic filler, of lactam(s) and/or lactone(s) in solution and/or in suspension in an organic liquid.

5. The particle as claimed in claim 1 , in which said particle is spheroidal.

6. The particle as claimed in claim 1 , in which said at least one cosmetic or pharmaceutical agent is a compound having a chemical formula identical to that of a skin compound.

7. The particle as claimed in claim 1 , in which said at least one cosmetic or pharmaceutical agent results from biofermentation.

8. The particle according to claim 1 , wherein the solubilizer is glycerol, propylene glycol, or a triglyceride.

9. A cosmetic, pharmaceutical or perfumery composition, comprising the particle of claim 1 .

10. The cosmetic, pharmaceutical or perfumery composition as claimed in claim 9 , said composition being a colored, colorless or transparent product selected from the group of products consisting of:
makeup products for the human face and body, foundation, tinted cream, loose powder, compact powder, eye-shadow, mascara, eyeliner, lipstick;
care products for the human face and body, cream, milk, lotion, mask, scrubbing product, cleansing and/or makeup removing products, deodorants, antiperspirants, shaving products, hair-removing products;
hair products, shampoos, product for the shaping of the hair, products for retaining the hairstyle, antidandruff products, products for combating hair loss, products for combating dryness of the hair, hair dyes, bleaching products;
perfumery products, fragrance, milk, cream, and loose or compact scented powder.

11. The cosmetic, pharmaceutical, or perfumery composition of claim 9 having an enhanced and/or prolonged diffusion into the stratum corneum after topical application of said product to the skin.

12. A process for the manufacture of particles of free polyamide-based powder impregnated with at least one cosmetic or pharmaceutical agent according to claim 1 , said process comprising the following successive stages:
adding dropwise or by spraying said cosmetic or pharmaceutical agent in the liquid state to particles of free polyamide base powder with stirring, so that said cosmetic or pharmaceutical agent represents at least 40% by weight of the powder particles, said particles being porous and having a specific surface area (SSA) of greater than 8 m 2 /g wherein the cosmetic or pharmaceutical agent is in the form of a pure liquid or as a solid dissolved in a solubilizer containing no solvent harmful to the skin, said solubilizer consisting of purified water, thermal water, glycerol, propylene glycol, a glyceride or an essential oil, said polyamide-based particle having a content, as molar percentage, of polyamide 12 of at least 50%, said cosmetic or pharmaceutical agent consisting of a lactic acid, a ceramide or a mixture thereof,
stopping the addition before the powder particles begin to agglomerate,
maintaining the stirring for at least 5 minutes, then
recovering the free powder obtained impregnated with said cosmetic or pharmaceutical agent.

13. The process as claimed in claim 12 , in which said at least one cosmetic or pharmaceutical agent is liquid at the temperature at which the addition is carried out.

14. The process as claimed in claim 12 , in which said particles have a mean diameter by volume within the range from 3 to 12 μm.

15. The process as claimed in claim 12 , in which said polyamide-based particles are chosen from particles of polyamide, copolyamide, copolyesteramide and their mixtures.

16. The process as claimed in claim 12 , in which said particles of polyamide-based powder are obtained at least in part by anionic polymerization, by seeding with an inorganic or organic filler, of lactam(s) and/or lactone(s) in solution and/or in suspension in an organic liquid.

17. The process as claimed in claim 12 , in which said particles are spheroidal.

18. The process as claimed in claim 12 , in which said particles comprise water.

19. The process as claimed in claim 12 , in which said at least one cosmetic or pharmaceutical agent comprises a compound with a chemical formula identical to that of a skin compound.

20. The process as claimed in claim 12 , in which said at least one cosmetic or pharmaceutical agent results from biofermentation.

Assignees

• Loyen Karine
• Arkema France

Inventors

• Loyen Karine

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61K8/68

  Sphingolipids, e.g. ceramides, cerebrosides, gangliosides · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61K8/365

  Hydroxycarboxylic acids; Ketocarboxylic acids · CPC title